Background: This retrospective study aims to evaluate the clinical course and long-term outcomes of patients diagnosed with adult granulosa cell tumors (AGCT). Methods: The study analyzed a cohort of 112 AGCT patients with a median follow-up of 87 months. Data regarding disease-free survival (DFS), overall survival (OS), recurrence rates, and prognostic factors were collected and analyzed. Surgical interventions, including lymphadenectomy and cytoreductive surgery, were assessed for their impact on outcomes. Results: The study revealed favorable long-term outcomes, with a 5-year DFS of 85% and a 10-year DFS of 83%. Additionally, a 5-year OS of 100% and a 10-year OS of 96% were observed. Recurrence occurred in 13.4% of cases, with advanced stage and positive peritoneal cytology identified as independent poor prognostic factors for DFS. Lymph node involvement was rare, and routine lymphadenectomy did not improve outcomes. Conservative surgery showed comparable DFS rates to definitive surgery in early-stage disease. However, cytoreductive surgery was crucial for advanced and recurrent tumors, with complete tumor resection enhancing survival outcomes. Conclusion: The study underscores the importance of vigilant follow-up and individualized treatment strategies for AGCT patients. Despite the retrospective nature of the analysis, the substantial patient cohort and meticulous surgical interventions contribute valuable insights into AGCT management. Prospective multicenter studies are warranted to further elucidate prognostic factors and optimize treatment approaches for this rare malignancy.

Background: Endometrial carcinoma, EC is the most common gynecologic malignancy in developed countries, and identifying accessible prognostic markers remains critical for guiding treatment strategies. Systemic inflammatory markers have emerged as promising tools in cancer prognosis. Objective: This study aimed to investigate the predictive value of the neutrophil percentage-to-albumin ratio, NPAR in patients diagnosed with endometrial carcinoma and to compare its utility with other systemic inflammatory indices. Methods: This retrospective study included 194 patients who underwent surgical treatment for endometrial carcinoma between January 2020 and May 2025 at a tertiary care center. Preoperative blood samples were used to calculate neutrophil percentage-to-albumin ratio, NPAR, neutrophil-to-lymphocyte ratio, NLR, platelet-to-lymphocyte ratio, PLR, systemic immune-inflammation index, SII, and other related markers. Patients were analyzed according to final pathological outcomes, and the relationship between inflammatory indices and prognostic parameters such as tumor grade, histologic type, depth of myometrial invasion, lymphovascular space invasion, LVSI and FIGO stage was evaluated. Receiver operating characteristic, ROC analysis was performed to determine optimal cutoff values for NPAR. Results: NPAR did not show a statistically significant association with lymphovascular space invasion (LVSI) or deep myometrial invasion. However, it was significantly associated with advanced stage (FIGO ≥ Stage II). High NPAR, elevated SIRI, high PLR, low NLR, elevated MLR, and increased immature granulocyte count were significant predictors of advanced stage. The regression model demonstrated strong predictive ability for advanced disease (Nagelkerke R² = 0.79; p < 0.001). Conclusion: NPAR is a novel, simple, and cost-effective prognostic biomarker in endometrial carcinoma. Its preoperative evaluation may help identify high-risk patients and contribute to more individualized treatment planning. Further prospective studies are warranted to validate these findings.

Purpose: This study investigates the effects of oral administration of Lactobacillus rhamnosus on the clearance of high-risk human papillomavirus (HR-HPV) and cervical cytology outcomes. Patients and Methods: In this retrospective observational study, histology results were analyzed from patient files and pathology reports of 218 patients who were positive for cervical HR-HPV DNA and had no evidence of high-grade cervical intraepithelial lesions. The study group (n=105) consisted of patients who had used V-Flora oral capsules containing L. rhamnosus and zinc for three months. We compared HR-HPV DNA and cervical cytology results between the study and control groups at 6 and 12 months. Results: No significant differences were found in HR-HPV clearance or cervical cytology results between users and non-users of L. rhamnosus at both 6 and 12 months (6 months hazard ratio: − 0.0228, 95% CI: − 0.1623 to 0.1167, p=0.777 and 12 months hazard ratio: − 0.1165, 95% CI: − 0.3467 to 0.1088, p=0.295). The hazard ratios and p-values indicate no significant impact on HR-HPV clearance or cytology outcomes, including in patients who remained HPV positive after 6 months (hazard ratio: − 0.1167, 95% confidence interval: − 0.3500 to 0.1165; p=0.333). Conclusion: The anticipated beneficial effects of oral administration of Lactobacillus rhamnosus on HR-HPV clearance and cervical cytology outcomes were not demonstrated in this study. Further research is needed to confirm these findings.

COVID-19 related immune dysregulation including impaired interferon signaling, reduced cytotoxic T-cell activity, and sustained inflammatory imbalance may

Amaç: Sistemik inflamatuar belirteçlerin endometrial intraepitelyel neoplazili ve grade 1 endometrioid tip endometrium kanserli hastalardaki farkı predikte etmedeki rolünü değerlenmektir. Gereç ve Yöntem: Eylül 2019- Temmuz 2023 tarihleri arasında tersiyer bir merkezde preoperatif endometrial biyopsi sonucu EİN olan 75 hasta ve grade 1 endometrioid tip endometrial kanser olan 223 hasta olmak üzere toplam 298 hastanın verileri hastane veri tabanından retrospektif olarak incelendi. İki grup arasındaki klinik ve biyokimyasal sonuçlar karşılaştırıldı. Bulgular: Endometrial intraepitelyal neoplazili ve grade 1 endometrioid tip endometrium kanserli hasta grupları arasında yaş ve inflamatuar prognostik indeks değerleri arasındaki fark istatistiksel olarak anlamlıydı(sırasıyla p