We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people.This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collect...

The activation of the sympathetic nervous system, which usually leads to a swift surge in blood pressure in the morning hours (MBPS) may be the cause of left ventricular hypertrophy (LVH) and endot...

Background/Objectives: Living kidney donors (LKDs) can be at risk of chronic kidney disease (CKD). Several conditions are associated with hyperfiltration, such as solitary kidney, obesity, and high protein consumption. In this regard, we aimed to evaluate the risk factors for kidney function decline in LKDs and the effect of daily protein intake. Methods: Data collected from 220 living kidney donors (mean age: 48.35 ± 12.4 years; 55% female) between 2016 and 2023 were evaluated. One-year and long-term outcomes were evaluated following donor nephrectomy, along with the risk factors for GFR decline and the development of CKD. Results: The percentage of eGFR decline was 31.15 (IQR: 19.81–37.5) in the first year and 28.18 (IQR: 18.75–38.16) in the third year after donation. None of the donors had end-stage renal disease during the 31 (IQR: 19–71) months. CKD developed in 31 (23.1%) LKDs. In the first year, the risk factors associated with a decline in eGFR exceeding 30% included male gender (OR: 0.25; 95% CI: 0.11–0.57; p: 0.001) and baseline eGFR value (OR: 0.95; 95% CI: 0.92–0.98; p: 0.002). At the final visit, the risk factors were male gender (OR: 7.19; 95% CI: 3.06–16.94; p < 0.001), age (OR: 1.06; 95% CI: 1.02–1.10; p: 0.001), and BMI (OR: 1.12; 95% CI: 1.01–1.23; p: 0.030). For the development of CKD, the risk factors were male gender (OR: 0.25; 95% CI: 0.09–0.71; p: 0.009) and baseline eGFR (OR: 0.88; 95% CI: 0.83–0.93; p < 0.001). No association was observed between daily protein intake and renal outcomes in LKDs following donor nephrectomy. Conclusions: In the present study, there was no significant unexpected decline in kidney function in donors in the short-term and the medium-term. Age, BMI, and low basal eGFR values should be carefully considered for LKD evaluation. Furthermore, our findings indicated that protein intake does not substantially impact the GFR. Further controlled studies are required to support our findings.

Background: Urinary tract infections (UTIs) are the most common infections after kidney transplantation and significantly affect patient outcomes. In these immunosuppressed patients, antibiotic resistance is of particular concern due to recurrent infections and limited treatment options. The aim of this study was to evaluate the distribution of microorganisms isolated from urine cultures of kidney transplant patients and to assess their antimicrobial susceptibility patterns. Methods: This retrospective study included all adult kidney transplant recipients with positive urine cultures during 2023–2024. Microorganisms were identified using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), and antimicrobial susceptibility testing was performed with the Phoenix System according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines. Results: A total of 363 urine samples from 123 patients (85% female) were analyzed. E. coli (49%) and Klebsiella spp. (24%) were the predominant uropathogens. High resistance rates to ciprofloxacin and trimethoprim–sulfamethoxazole (TMP–SMX) were observed in both species, while carbapenem resistance remained low. Elevated resistance to multiple antibiotics was also detected among Pseudomonas aeruginosa and Acinetobacter spp., highlighting the importance of continued microbiological surveillance in this population. Conclusions: Gram-negative bacteria were the predominant pathogens causing UTIs in kidney transplant recipients. The high resistance rates to ciprofloxacin and TMP–SMX emphasize the need for local antimicrobial surveillance and individualized empirical therapy. Systematic and ongoing monitoring of resistance patterns is essential to optimize infection management in this vulnerable patient group.

Background/Objectives: We aimed to analyse the development of acute kidney injury (AKI), its association with mortality, and mortality-associated factors in patients admitted to the intensive care unit (ICU) with sepsis. Methods: This retrospective cohort study was conducted on adult patients with sepsis admitted to the ICU of a tertiary-care hospital between January 2023 and December 2023. Demographic, clinical, and laboratory data within the first 24 h of admission to the ICU were recorded. These data were compared between patients with and without sepsis-associated acute kidney injury (SA-AKI). Results: Among 1163 admissions, 185 met the study criteria, and the incidence of SA-AKI was 45.4%. The overall 28-day mortality was 38.4%. Patients with SA-AKI had significantly higher mortality than those without SA-AKI (63.1% vs. 17.8%, p < 0.001). In the multivariable Cox regression analysis, SA-AKI was independently associated with a higher risk of 28-day mortality (HR = 2.87, 95% CI 1.51–5.45, p = 0.001). Among patients with SA-AKI, elevated lactate showed a borderline association with mortality (HR = 1.06 per mmol/L, 95% CI 1.00–1.13, p = 0.053); first-day vasopressor use was not independently associated with mortality after adjustment for illness severity. Conclusions: SA-AKI was independently associated with higher 28-day mortality. Within the SA-AKI subgroup, lactate showed only a borderline association with mortality, whereas first-day vasopressor use appeared to reflect illness severity.

Background/Objectives: Urinary tract infections (UTIs) are common infectious complications in kidney transplant recipients (KTRs) and non-transplant nephrology patients. However, direct culture-based comparisons of urinary isolate distribution and antimicrobial resistance profiles between KTRs and non-transplant nephrology (NTN) patients remain limited. This study compared urinary isolates recovered from urine cultures with significant growth and their in vitro antimicrobial resistance profiles in hospitalized KTRs and NTN patients. Methods: In this retrospective culture-based study, urine culture results from patients hospitalized in the nephrology and kidney transplantation units between 1 January 2024 and 31 December 2025 were reviewed. Urinary isolate distribution, in vitro antimicrobial resistance profiles, and extended-spectrum β-lactamase (ESBL) production were compared between the two. Results: A total of 397 patients with at least one urine culture showing significant growth were included, comprising 220 KTRs and 177 NTN patients. Enterobacterales were significantly more frequent among KTRs than among NTN patients (77.2% vs. 41.1%, p < 0.001). Escherichia coli was the predominant urinary isolate in both groups. In contrast, Candida spp. (26.8% vs. 3.2%, p < 0.001), Enterococcus spp. (15.8% vs. 7.7%, p < 0.001), and non-fermenting Gram-negative bacteria (9.4% vs. 3.4%, p = 0.001) were more frequently recovered from NTN patients. Among E. coli isolates, resistance to gentamicin (p = 0.006) and ertapenem (p = 0.001) was significantly higher in the NTN group. Likewise, Klebsiella pneumoniae isolates from NTN patients showed significantly higher resistance to third-generation cephalosporins, aminoglycosides, and carbapenems (p < 0.05). ESBL production was also more frequent in NTN patients than in KTRs (55.7% vs. 41.9%, p = 0.013). Conclusions: Hospitalized KTRs and NTN patients exhibited distinct urinary isolate distributions and in vitro antimicrobial resistance profiles. These findings should be interpreted as culture-based epidemiological data rather than as differences in clinically confirmed UTI burden. Stratified local surveillance may help contextualize urinary isolate and susceptibility patterns across hospitalized nephrology populations.