Organizational agility and ambidextrous leadership foster flexibility, creativity, and collaboration, which are essential for preparing nurses to embrace change. This study aimed to examine the impact of organizational agility and ambidextrous leadership on nurses’ readiness for change. Using a descriptive correlational design, data were collected from 348 nurses at Al‐Rajhi and Heart Hospitals affiliated with Assiut University through validated scales on organizational agility, ambidextrous leadership, and readiness for change. Results showed that ambidextrous leadership had the strongest positive effect on nurses’ readiness for change ( β = 0.570, p < 0.001), followed by organizational agility ( β = 0.205, p < 0.001). In conclusion, this study underscores the pivotal role of ambidextrous leadership and organizational agility in enhancing nurses’ readiness for change. By fostering adaptive leadership behaviors and agile organizational practices, healthcare institutions can cultivate environments that promote innovation and facilitate effective change implementation. Therefore, strengthening these dimensions among nursing leaders is essential to sustain continuous improvement and ensure the success of healthcare reform initiatives. Training programs to enhance ambidextrous leadership skills among nurse leaders are recommended to balance exploratory and exploitative behaviors and drive readiness for change.

Objectives: This study aimed to (1) assess healthcare workers’ (HCWs) knowledge and attitudes toward mpox across 3 Gulf countries, and (2) examine factors influencing their acceptance of the mpox vaccine using the health belief model (HBM). This model evaluated perceptions related to susceptibility, severity, benefits, barriers, cues to action, and self-efficacy. Additionally, the study explored the impact of prior coronavirus disease 2019 (COVID-19) vaccination history on mpox vaccine acceptance.Methods: A cross-sectional study was conducted among 764 HCWs from the United Arab Emirates (UAE), Saudi Arabia, and Qatar. Data were collected through a structured online questionnaire based on HBM constructs. Logistic regression and structural equation modeling were employed to analyze predictors of vaccine acceptance.Results: Knowledge levels varied across the countries, with the highest proportion of good knowledge reported in the UAE (59%). UAE HCWs also demonstrated higher perceived susceptibility, perceived benefits, and intention to vaccinate compared to those in Saudi Arabia and Qatar (p<0.001). Receiving 4 doses of the COVID-19 vaccine was associated with greater acceptance of the mpox vaccine. Among the HBM constructs, perceived benefits and self-efficacy were identified as the strongest predictors of vaccine acceptance. Perceived barriers, such as fear of side effects and concerns about vaccine safety, were more prominent among HCWs in Saudi Arabia and Qatar.Conclusion: The HBM effectively explains the factors influencing mpox vaccine acceptance among Gulf HCWs. Targeted interventions that improve perceived benefits, reduce barriers, and improve self-efficacy may facilitate greater vaccine uptake and preparedness for emerging infectious diseases.