The declassification of Cold War-era, US spy satellite imagery, collectively known as the Keyhole imagery, has contributed to hundreds of research projects across disciplines including geography, ecology, glaciology, archaeology, heritage studies, and urban studies. Corona (KH-4) and, increasingly, Hexagon (KH-9) imagery has garnered attention and excitement throughout the scientific community. The worldwide, repeat coverage and high resolution (up to 0.6m) of this imagery, which also has stereo coverage, is exceptional and not replicated elsewhere; it is also low-cost. However, declassified imagery has complex geometries and issues associated with processing and modeling. Even the initial imagery selection can deter adoption. This article addresses the critical issues involved with manipulating these declassified imagery. It synthesizes dozens of case studies across scientific domains to draw out commonalities in experiences at the selection, processing, and modeling stages. Issues with the image scans and ordering process, over- and underavailability of imagery, mosaicking, lack of metadata, ground control points, rigorous modeling, and image size are outlined. Approaches help guide researchers towards tailored solutions. Approaches to efficiently and effectively sort through imagery archives and georeferencing software options, and data management strategies are discussed. Two open-access tools for modeling, Sunspot and Ames Stereo Pipeline, are highlighted. The aim throughout is to increase the use of declassified historical imagery by orienting researchers to issues they can anticipate and approaches they can employ. The article represents the most comprehensive discussion of methods associated with declassified imagery published to date, that will enable accessibility and innovation.