Objective: This in vitro study aimed to compare the layer-matched color compatibility of three 3Y/4Y/5Y multilayer zirconia grades marketed in shade A2. Materials and Methods: Disc specimens (18 mm × 1.5 mm) were milled from pre-shaded multilayer zirconia blanks (Katana™ Multi-Layered Zirconia; Kuraray Noritake Dental Inc., Tokyo, Japan) in three grades: UTML (5Y), STML (4Y), and HTML (3Y). Twelve discs per grade were polished and measured on a neutral-gray background (Munsell N7) using a dental spectrophotometer (VITA Easyshade Advance 4.0; VITA Zahnfabrik, Bad Säckingen, Germany) at the incisal, middle, and cervical thirds. Color differences were calculated using CIEDE2000 (ΔE₀₀). Yttria content (wt%) was determined using EDS (JSM-7800F; JEOL Ltd., Tokyo, Japan), and phases were assessed using XRD (X’Pert PRO; Malvern Panalytical, Almelo, The Netherlands); microstructure and grain size were examined using FE-SEM after thermal etching. Statistics: A two-way mixed-design ANOVA with Bonferroni adjustment (α = 0.05) was conducted. Results: A significant incisal-to-cervical gradient was observed within each grade (p < 0.001), whereas layer-matched inter-material differences were small (all ΔE00 < 1.0), i.e., below the commonly accepted perceptibility threshold. EDS confirmed the expected stepwise decrease in Y₂O₃ from UTML to HTML, accompanied by corresponding changes in phase constitution and grain size. Conclusions: Despite compositional and microstructural differences, the three multilayer zirconia grades showed no clinically perceptible layer-matched color differences, supporting their combined use in extended rehabilitations while maintaining the natural-like color gradient across the multilayer blank.

Background/Objectives: Residual EDTA may persist after smear-layer removal and after the application of contact sealers during setting. This in vitro study compared the effect of 1 min of pre-setting surface contact with 17% EDTA (vs. distilled water) on a calcium silicate-based sealer (AH Plus Bioceramic Sealer) and an epoxy resin-based sealer (AH Plus). Methods: Discs were prepared (N = 108) in a 2 × 2 design (n = 27/group); per group; n = 12 were used for solubility followed by eluate pH using the same specimens/eluates after 24 h immersion in distilled water; n = 12 were used to test Vickers microhardness on an independent set after setting; and n = 3 were used for SEM/EDS. Results: Data were analyzed at α = 0.05 using Kruskal–Wallis tests followed by Bonferroni-adjusted pairwise Mann–Whitney U tests for solubility and eluate pH, and one-way ANOVA was performed followed by Tukey’s post hoc test to assess the microhardness. Solubility differed among groups (p < 0.001) and was higher for the bioceramic sealer than for the resin sealer; pre-setting EDTA exposure increased solubility for the AH Plus Bioceramic Sealer (0.86 ± 0.08% to 1.30 ± 0.16%) and decreased solubility for AH Plus (0.34 ± 0.04% to 0.22 ± 0.03%) (p < 0.05). The eluate pH also differed among groups (p = 0.001) and was higher for the bioceramic sealer (≈11.7) than for the resin sealer (≈8.7–9.3), with no within-material differences (p = 0.999 and p = 0.851). Microhardness differed among groups (p < 0.001) and was higher for AH Plus (239.70–246.92 HV) than for AH Plus Bioceramic (131.72–170.83 HV); EDTA reduced microhardness only for the bioceramic sealer (p < 0.001), with no significant change for AH Plus (p = 0.475). Descriptive SEM/EDS findings suggested increased surface irregularities and lower surface Ca for AH Plus Bioceramic after EDTA exposure (12.68 to 7.31 wt%). Conclusions: Pre-setting EDTA contact therefore produced material-dependent changes in early properties and adverse surface-related effects in the calcium silicate-based sealer, supporting thorough chelator removal before obturation.

Background/Objectives: Lithium disilicate (LD) veneers are widely used for minimally invasive anterior rehabilitation because of their favorable optical and mechanical properties. Fully digital workflows have been proposed as alternatives to conventional milling. These approaches combine computer-aided design and manufacturing (CAD/CAM) with 3D-printed burn-out patterns and subsequent heat pressing of LD ingots. However, clinical documentation of multi-unit anterior cases fabricated exclusively through this additive-plus-pressing route remains scarce. This case report aims to describe a fully digital additive-plus-pressing workflow for four maxillary anterior LD veneers and to report 48-month clinical outcomes. Case Presentation: A 52-year-old female presented with esthetic concerns involving the maxillary central and lateral incisors (teeth 11, 12, 21, and 22). After clinical and radiographic evaluation, a minimally invasive veneer-based rehabilitation was planned. Preparations were performed under magnification, and immediate dentin sealing was applied. Digital impressions were obtained with an intraoral scanner, and veneers were designed using CAD software(Exocad DentalDB 3.0 Galway (Exocad GmbH, Darmstadt, Germany). Castable resin patterns were 3D-printed, invested, and heat-pressed using LD ingots, followed by finishing and glazing. Adhesive cementation was performed under rubber dam isolation after hydrofluoric acid etching and silanization of the intaglio surfaces and conditioning of the tooth substrates according to the adhesive protocol, using a dual-cure resin cement. At the 48-month follow-up, all veneers remained intact, with clinically acceptable marginal adaptation, stable color and surface gloss, and no signs of secondary caries or marginal discoloration. The patient reported sustained esthetic satisfaction and comfortable function without postoperative sensitivity. Conclusions: This single-patient report suggests that a fully digital additive-plus-pressing workflow may be clinically viable for high-demand anterior LD veneers, providing favorable medium-term esthetics and patient-centered outcomes with no technical or biological complications. The reproducible protocol described may facilitate the integration of 3D printing and heat pressing into digital veneer rehabilitation and supports further controlled clinical investigations.