María Clara Santía

Dr. María Clara Santía


Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 July 2025 in Cancers
Verified
Journal Article
Open access
PDF file
MSMaría Clara Santía
María Clara Santía
TMTommaso Meschini
Tommaso Meschini
HHHeng-Cheng Hsu
Heng-Cheng Hsu
PMPaula Mateo-Kubach
Paula Mateo-Kubach
EYElise M. Yates
Elise M. Yates
PRPedro T Ramirez
Pedro T Ramirez
The recommended treatment for early-stage cervical cancer (FIGO 2018 stages IA–IB2 and selected IIA1) is surgery, followed by either observation or adjuvant therapy, based on individual risk factors. Surgical management has evolved from extensive radical procedures to more conservative strategies, allowing for fertility-preserving options in appropriately selected patients. In 2018, a landmark study (LACC trial) evaluated the surgical approach to radical hysterectomy, comparing open vs. minimally invasive surgery. The results demonstrated that minimally invasive surgery was associated with worse disease-free and overall survival, leading to guidelines changes that recommend the open radical hysterectomy as the new standard of care. More recently, results from the prospective randomized SHAPE trial demonstrated that in well-selected patients with low-risk early-stage cervical cancer, recurrence rates are comparable between simple hysterectomy and radical hysterectomy. An ongoing study, the CONTESSA trial, is evaluating the role of neoadjuvant chemotherapy in the setting of fertility preservation for lesions measuring 2–4 cm. In addition, ongoing studies are evaluating different surgical approaches for both simple hysterectomy (LASH trial) and radical hysterectomy (ROCC/GOG-3043 and RACC trials), with a focus on comparing oncologic outcomes. Attention has also turned to refining lymph node assessment. Sentinel lymph node biopsy has become a standard staging strategy with reduced morbidity. The SENTICOL I-II and SENTIX/ENGOT-Cx2 trials support its safety and diagnostic accuracy in early-stage disease. This article offers a comprehensive overview of recently published prospective trials that have shaped clinical practice in the management of early-stage cervical cancer. It focuses on surgical approaches and radicality, the role of sentinel lymph node mapping, and fertility-sparing treatments. The review further draws attention to ongoing investigations and novel studies that may influence future directions in the field.

3 May 2025 in International Journal of Gynecological Cancer
Verified
Journal Article
Closed access
MSMaría Clara Santía
María Clara Santía
VAVanessa Alvarenga-Bezerra
Vanessa Alvarenga-Bezerra
WCWilliam Andrés Piñeros Castillo
William Andrés Piñeros Castillo
CMCarolina Morante-Caicedo
Carolina Morante-Caicedo
HHHeng-Cheng Hsu
Heng-Cheng Hsu
FNFlorencia Noll
Florencia Noll