Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration. Among them, acetyl hexapeptide-8 (AH-8), often referred to as a “botox-like” peptide, has received considerable attention for its potential to dynamically reduce wrinkles through the modulation of neuromuscular activity. AH-8 is widely used in topical formulations intended for anti-aging effects, scar treatment, and skin rejuvenation. This review provides a comprehensive overview of the structure and proposed mechanisms of action of AH-8, with particular focus on its efficacy and skin penetration properties. Due to its hydrophilic nature and relatively large molecular size, AH-8 faces limited permeability through the lipophilic stratum corneum, making effective dermal delivery challenging. Formulation strategies such as oil-in-water (O/W) and multiple water-in-oil-in-water (W/O/W) emulsions have been explored to enhance its delivery, but the ability of AH-8 to reach neuromuscular junctions remains uncertain. Preclinical and clinical studies indicate that AH-8 may reduce wrinkle depth, improve skin elasticity, and enhance hydration. However, the precise biological mechanisms underlying these effects—particularly the peptide’s ability to inhibit muscle contraction when applied topically—remain incompletely understood. In some studies, AH-8 has also shown beneficial effects in scar remodeling and sebum regulation. Despite promising cosmetic outcomes, AH-8’s low skin penetration limits its bioavailability and therapeutic potential. This review emphasizes the need for further research on formulation science and delivery systems, which are essential for optimizing the effectiveness of peptide-based cosmeceuticals and validating their use as non-invasive alternatives to injectable treatments.

Introduction: Major manifestations of facial skin aging include the loss of firmness and elasticity, the appearance of wrinkles, and various pigmentary changes. Mesotherapy—both needle and microneedle-based—is a commonly chosen procedure that effectively revitalizes and stimulates the skin. The aim of this study was to compare the effectiveness of both techniques in reducing the signs of skin aging using a product containing fragmented hyaluronic acid and an amino acid complex. Materials and Methods: The study included 20 female participants aged 35–60 years who underwent a series of four treatment sessions in a split-face design. One side of the face was treated with needle mesotherapy, while the other side received microneedle mesotherapy. In each session, 5 mL of a preparation containing fragmented hyaluronic acid, glutathione, stabilized vitamin C, and an amino acid complex was administered. Skin parameters (hydration, pH, sebum level, erythema, and pigmentation), photographic documentation, participants’ subjective evaluations, and pain scores were assessed. Results: Both techniques led to significant improvements in skin condition. Microneedle mesotherapy was more effective in enhancing hydration, regulating sebum and pH, and was better tolerated in terms of pain. Needle mesotherapy demonstrated greater efficacy in reducing pigmentation. Patient satisfaction was high in both groups. Conclusions: Both needle and microneedle mesotherapy are effective treatments for aging skin, although their mechanisms of action differ. The choice of technique should be tailored to the individual needs of the skin and the expectations of the patient.

Stretch marks are a common problem and a challenge for cosmetologists and aesthetic medicine doctors. Due to the complex etiopathogenesis and difficulties in their reduction, specialists use various therapeutic methods. In this study, the described case confirms the effectiveness of selected combined therapy in reducing stretch marks and skin laxity. Impressive surgical results were obtained with the implementation of combined therapy consisting of the use of non-ablative Nd:YAG fractional laser and alexandrite laser in picosecond technology, CO2 fractional ablative laser and needle mesotherapy treatments.

Introduction: Onychomycosis is a common fungal nail infection that poses a significant therapeutic challenge, particularly in the elderly population. The use of pharmacological monotherapy alone is often insufficient. Aim: The study aimed to present the course of diagnostic and therapeutic management in a man with onychomycosis of rare yeast etiology. Materials and methods: A 92-year-old man was diagnosed with a severe fungal infection of the left big toenail caused by an atypical yeast-like pathogen of the genus Rhodotorula. Combination therapy was administered, consisting of systemic pulse therapy with itraconazole and podiatric procedures. Changes in the color and texture of the nail plate were assessed using digital image analysis. Results: After four cycles of pulsed itraconazole therapy and three sessions of mechanical nail plate treatment, clinically visible lesions resolved. Conclusions: The combination of systemic itraconazole therapy with mechanical nail plate treatment was associated with clinical improvement. Collaboration between a dermatologist and a podiatrist may serve as a complementary component of management in elderly patients. Digital analysis of color and texture parameters may support photographic documentation; however, its usefulness as a tool for assessing treatment efficacy requires further validation.

The skin serves not just a protective function, but also significantly influences body image and social relationships. Consequently, dermatological issues, including acne, eczema, psoriasis, and atopic dermatitis, can yield substantial psychological repercussions for individuals impacted. This study aimed to investigate the correlation between dermatological issues and mental health, emphasising the influence of emotions, stress, and body image on the psychological well-being of individuals. The significance of a comprehensive strategy in the management of dermatological patients was underscored. Findings indicate that people with chronic dermatological conditions are more likely to experience anxiety disorders, depression and reduced self-esteem. Skin problems can lead to social isolation and exacerbate negative emotions such as shame and frustration. Stress, as a reaction to these challenges, can further exacerbate skin symptoms, creating a vicious cycle between physical and psychological conditions. The results indicate a necessity for enhanced cooperation between dermatologists and psychologists in the management of patients with persistent skin disorders.

The body’s natural ageing process is characterised by a decrease in skin volume and the development of deeper wrinkles. Fillers derived from cross-linked hyaluronic acid are commonly used in aesthetic medicine procedures, however they are frequently overused. Current investigations are underway to new solutions that can be utilised in therapies aimed at regenerating damaged tissues and enhancing the appearance of the skin. Collagen stimulators, which include both type I and type III, consist of amino acids, fragmented uncrosslinked hyaluronic acid, biomimetic peptides, polynucleotides, and polymers. The above compounds serve as alternatives to crosslinked hyaluronic acid. This study aimed to introduce powdered polydioxanone containing microspheres as a product that promotes the production of collagen. This synthetic polymer can be used by patients seeking to rejuvenate facial skin by restoring its tone, density, and natural volume. Due to its hydrophilic properties, immune neutrality, and ability to degrade into water and carbon dioxide, powdered polydioxanone seems to be a safe option for aesthetic medicine procedures.