The accurate extraction of navigational regions from images of navigational waters plays a key role in ensuring on-water safety and the automation of unmanned vessels. Nonetheless, current technological methods encounter significant challenges in addressing fluctuations in water surface illumination, reflective disturbances, and surface undulations, among other disruptions, in turn making it challenging to achieve rapid and precise boundary segmentation. To cope with these challenges, in this paper, we propose a coordinate-aware multi-scale feature network (GASF-ResNet) method for water segmentation. The method integrates the attention module Global Grouping Coordinate Attention (GGCA) in the four downsampling branches of ResNet-50, thus enhancing the model’s ability to capture target features and improving the feature representation. To expand the model’s receptive field and boost its capability in extracting features of multi-scale targets, the Avoidance Spatial Pyramid Pooling (ASPP) technique is used. Combined with multi-scale feature fusion, this effectively enhances the expression of semantic information at different scales and improves the segmentation accuracy of the model in complex water environments. The experimental results show that the average pixel accuracy (mPA) and average intersection and union ratio (mIoU) of the proposed method on the self-made dataset and on the USVInaland unmanned ship dataset are 99.31% and 98.61%, and 98.55% and 99.27%, respectively, significantly better results than those obtained for the existing mainstream models. These results are helpful in overcoming the background interference caused by water surface reflection and uneven lighting in the aquatic environment and in realizing the accurate segmentation of the water area for the safe navigation of unmanned vessels, which is of great value for the stable operation of unmanned vessels in complex environments.