Background: Maternal Hypertensive Disorders (MHD), encompassing gestational hypertension, chronic hypertension, preeclampsia, and eclampsia, which was a significant contributor to maternal morbidity and mortality, particularly in regions with lower socioeconomic status. Methods: Using data from the 2021 Global Burden of Disease (GBD) study, we analyzed the burden of MHD globally. We used the slope index and concentration index to measure cross-country inequality in MHD burden, and employed a Bayesian age-period-cohort (BAPC) model to project the burden from 2022 to 2045. Additionally, we conducted a two-sample Mendelian randomization (MR) analysis based on genome-wide association study (GWAS) to investigate potential causal relationships between occupational exposures and MHD. Results: Overall, the global incidence, prevalence, mortality, and DALYs for MHD have declined. However, incidence and prevalence rose in Central Asia, Eastern Europe, and Western Europe, while the Caribbean increasing in mortality and DALYs. Iron deficiency emerged as the leading risk factor. Significant SDI-related inequalities in MHD burden were observed, especially in lower SDI countries. Projections suggest ongoing reductions in MHD burden through 2045. MR results revealed a significant causal link between frequent exposure to chemical or other fumes in the workplace and MHD, while no clear causal relationships were identified for particulate matter or other assessed exposures. Conclusions: Although the global MHD burden is decreasing, marked regional disparities persist. Efforts focusing on addressing iron deficiency, improving nutritional support, and mitigating occupational exposures may further reduce the burden. Strengthening maternal healthcare services—especially in low-SDI will be crucial for achieving sustainable declines in MHD worldwide.

Atrial fibrillation/flutter (AF/AFL) poses significant risks of heart failure and stroke. From 1990 to 2021, China's AF/AFL cases surged from 3.20 to 10.78 million. Using Global Burden Disease (GBD) 2021 data and Bayesian age‐period‐cohort (BAPC) modeling, we analyzed trends and projected disease burden through 2045. Age‐standardized incidence and prevalence rose by 5.4% and 14.5%, respectively, while mortality and disability‐adjusted life year (DALY) rates declined by 12.2% and 3.8%. By 2045, prevalent cases may reach 23.04 million, with 1.93 million new cases, 220 000 deaths, and 4.21 million DALYs. Key risk factors include hypertension, smoking, high‐sodium diet, and obesity. Sex disparities emerged, with females showing better mortality/DALY improvements than males. Population aging and metabolic risks will drive future burden. Targeted interventions (blood pressure control, smoking cessation, sodium reduction) and sex‐/age‐specific strategies are critical. Innovations in digital health (AI monitoring) and tiered healthcare networks could mitigate risks. Prioritizing China‐specific prevention frameworks is essential to address this escalating public health challenge. Geriatr Gerontol Int 2025; 25: 1047–1057 .

This study aimed to analyze the global, regional, and national burden of atrial fibrillation (AF) in women of childbearing age (WCBA) from 1990 to 2021, to identify trends and disparities and to project the future burden of AF in population. Data from the GBD 2021 were used to estimate the burden of AF in WCBA. Age-standardized rates (ASRs) of incidence, prevalence, disability-adjusted life years (DALYs), and mortality rate were calculated from 1990 to 2021. Joinpoint regression and Bayesian age-period-cohort analysis were applied to assess temporal trends, regional disparities, and to project future AF burden. From 1990 to 2021, the global number of AF cases in WCBA increased by 71,092 thousand, with increasing trends in incidence [estimated annual percentage change (EAPC = 0.99)], prevalence (EAPC = 1.23), DALYs (EAPC = 1.04) and mortality (EAPC = 0.69). The burden of AF was higher in high Socio-Demographic Index (SDI) areas than in low SDI areas, particularly in terms of ASPR per 100,000 (44.48 > 25.35), highlighting health inequalities. The burden of AF is particularly high in women over 40 years of age, peaking at 45–49 years of age, due to the accumulation of risk factors such as hypertension and body mass index. Projections suggest that the burden of AF will continue to increase globally, especially in low and medium SDI countries. The burden of AF in WCBA is increasing globally, with significant regional disparities. Effective public health interventions targeting key risk factors of hypertension and BMI. International cooperation and comprehensive health strategies are essential to reduce health inequities and improve AF prevention and management among WCBA. What is already known on this topic The trend and the burden of AF in global has been known. What this study adds The incidence, prevalence, DALYs, and mortality of AF in WCBA showed an increasing trend globally. Projections indicate a continued rise in AF burden globally, especially in low- middle SDI countries. How this study might affect research, practice or policy International collaboration and comprehensive health strategies play a vital role in reducing health disparities and enhancing the prevention and management of AF among women of childbearing age.