The city of Uvira, located in the eastern Democratic Republic of Congo (DRC), is increasingly experiencing flood events with devastating impacts on human life, infrastructure, and livelihoods. This study evaluates flood susceptibility in Uvira using Geographic Information Systems (GISs), and an Analytical Hierarchy Process (AHP)-based Multi-Criteria Decision Making approach. It integrates eight factors contributing to flood occurrence: distance from water bodies, elevation, slope, rainfall intensity, drainage density, soil type, topographic wetness index, and land use/land cover. The results indicate that proximity to water bodies, drainage density and slope are the most influential factors driving flood susceptibility in Uvira. Approximately 87.3% of the city’s land area is classified as having high to very high flood susceptibility, with the most affected zones concentrated along major rivers and the shoreline of Lake Tanganyika. The reliability of the AHP-derived weights is validated by a consistency ratio of 0.008, which falls below the acceptable threshold of 0.1. This research provides valuable insights to support urban planning and inform flood management strategies.