Background: Cirrhosis represents an advanced stage of hepatic fibrosis, and the metabolic changes resulting from liver dysfunction can cause impairment in physical capacity and quality of life. This study aimed to evaluate the effect of 12 weeks of resistance exercise on inflammatory markers, oxidative stress, physical conditioning, and quality of life in patients with liver cirrhosis. Methods: A total of 38 patients paired in the exercise (EG) and control (CG) groups participated in this study. The EG submitted to two weekly sessions of a program composed of resistance exercises. We evaluated the inflammatory markers (IL-6, IL-10, and TNF-α), oxidative stress (carbonylated protein, total thiols, enzyme superoxide dismutase, and catalase activity), body composition, handgrip strength (HGS), total volume of training, cardiorespiratory capacity (VO₂, VCO₂, and VE_peak), exercise capacity, and quality of life. Results: Regarding the EG, when comparing the follow-up period to the baseline, significant differences (p < 0.05) were found in BMI, HGS, total training volume, cardiorespiratory capacity variables, the 6 min walk test, and quality of life. Improvements were observed, without significant differences, in the inflammatory profile, oxidative stress, and one of the markers of liver function. The CG showed a significant decrease (p < 0.05) in HGS and cardiorespiratory capacity after the intervention. Conclusions: In patients with liver cirrhosis, a resistance exercise program improved physical fitness and quality of life, without adverse events. In addition, it seems that this type of training can bring some benefit to the inflammatory profile and oxidative stress of this population.

Ischemic preconditioning (IPC) is defined as brief periods of ischemia, interspersed by reperfusion that precedes a period of sustained ischemia. Unlike what happens in the clinical area where the application of the maneuver has been extensively investigated but as for the association of IPC with sport there are still few studies. Although the data already known can provide important subsidies for its use in sports. The aim to analyze the acute effect of IPC in first half of a soccer match on young soccer players' physical performance and heart rate. The sample consisted of 10 male athletes from the sub-15 categories (64.5 ± 5.8 Kg; 1.79 ± 0.1 m; 20.2 ± 1.1 Kg/m²). The volunteers were randomly divided with balanced input in following experimental sessions: a) IPC (4 x 5 minutes at 220 mmHg / 0 mmHg) + Soccer Match; b) SHAM (4 x 5 minutes at 20 mmHg / 0 mmHg) + Soccer Match and, c) Control + Soccer Match. The time-dependency was 60 to 75 minutes before the match, with an interval of seven days between the sessions. The first half of a soccer match was used for analysis. ANOVA was used to compare the number of sprints, total distance traveled, number of accelerations, and heart rate. There was no statistically significant difference between IPC vs. SHAM vs. Control Session in the first half of a soccer match for the number of sprints, total covered distance, number of accelerations, and the minimum, average and maximum heart rate (p>0.05). Our findings indicate that the IPC does not improve young soccer players' physical performance and heart rate in the first half of a soccer match.

Background: Cirrhosis represents an advanced stage of hepatic fibrosis, and the metabolic changes resulting from liver dysfunction can cause impairment in physical capacity and quality of life. This study aimed to evaluate the effect of 12 weeks of resistance exercise on inflammatory markers, oxidative stress, physical conditioning, and quality of life in patients with liver cirrhosis. Methods: 38 patients paired in the exercise (EG) and control (CG) groups participated in the study. The EG submitted to 2 weekly sessions of a program composed of resistance exercises. We evaluated the inflammatory markers (IL-6, IL-10, and TNF-α), oxidative stress (carbonylated protein, total thiols, enzymes superoxide dismutase and catalase activity), body composition, handgrip strength (HGS), and total volume of training, cardiorespiratory capacity (VO2, VCO2 and VEpeak), exercise capacity and quality of life. Results: Regarding the EG, when comparing the follow-up moment to the baseline, significant differences (p<0.05) were found in BMI, HGS, total training volume, cardiorespiratory capacity variables, 6-min walk test, and quality of life. Improvements were observed, without significant differences, in the inflammatory profile, oxidative stress, and in one of the markers of liver function. The CG showed a significant decrease (p<0.05) in HGS and cardiorespiratory capacity after the intervention. Conclusions: In patients with liver cirrhosis, a resistance exercise program improved physical fitness and quality of life, without adverse events. Besides, it seems that this type of training can bring some benefit to the inflammatory profile and oxidative stress of this population.