As key nodes in the energy transmission network, oil and gas pipeline stations are crucial in ensuring national energy security and stable economic development. The traditional construction mode of “on-site prefabrication and installation” has problems, such as low efficiency, high cost, and large quality fluctuations, which make it difficult to meet current construction needs. Factory prefabrication technology for pipelines has become a key path to solving industry pain points. This article focuses on the factory prefabrication technology of oil and gas station pipelines. By integrating key technologies, such as 3D modeling, automated welding, modular transportation, and intelligent detection, the visualization and digitization of station pipeline design are achieved, providing a basis for prefabrication and processing. They also improve welding quality and efficiency through automated welding technology and non-destructive testing technology. Through research on the planning and construction of prefabrication factories, construction organization and quality management, supply chain management, and information technology applications, real-time monitoring and information management of the construction process have been achieved. Case analysis shows that factory prefabrication can achieve a prefabrication rate of 70% for DN50–DN600 pipelines in the station, 80% for automated welding seams, a total construction period reduction of about 30%, a one-time welding qualification rate of over 96%, and a significant cost reduction, reflecting the significant advantages of factory prefabrication in terms of construction period, quality, and cost. Further research has clarified that factory prefabrication technology can effectively improve the efficiency, quality, and economic benefits of pipeline construction in oil and gas stations, promote the transformation of construction towards a high-efficiency, low-carbon, and sustainable direction, and provide support for the strategic goal of “One National Network”.