Conventional ammonia production uses fossil-based hydrogen, resulting in high greenhouse gas emissions. Given the growing demand for sustainable solutions, it is essential to replace fossil hydrogen with renewable alternatives. This study assessed the technical, economic, and environmental viability of renewable ammonia production in Minas Gerais. To this end, an optimization model based on mixed integer linear programming (MILP) was developed and implemented in LINGO 20^® software. The model incorporated investment costs; raw materials; transportation; emissions; and indicators such as NPV, payback, and minimum sale price. Hydrogen production routes integrated into the Haber–Bosch process were analyzed: biomass gasification (GS_WGS), anaerobic digestion of vinasse (Vinasse_BD_SMR), ethanol reforming (Ethanol_ESR), and electrolysis (PEM_electrolysis). Vinasse_BD_SMR showed the lowest costs and the greatest economic viability, with a payback of just 2 years, due to the use of vinasse waste as a raw material. In contrast, the electrolysis-based route had the longest payback time (8 years), mainly due to the high cost of the electrolyzers. The substitution of conventional hydrogen made it possible to avoid 580,000 t CO₂ eq/year for a plant capacity of 200,000 t NH₃/year, which represents 13% of the Brazilian emissions from the nitrogenated fertilizer sector. It can be concluded that the viability of renewable ammonia depends on the choice of hydrogen source and logistical optimization and is essential for reducing emissions at large scale.