A novel lightweight diagnostic film with sensors/actuators and a multiple-path wiring option using inkjet printing was developed. The diagnostic film allows for systematic, accurate, and repeatable sensor placement. Furthermore, the film is highly flexible and adaptable for placement on complex configurations. The film can be attached to the surface of the structure through a uniform secondary boundary procedure or embedded within the composite layup during curing. The surface-mounted film can simply be peeled off for repair or replacement without scratching or damaging the part. The film offers significant weight reduction compared to other available technologies. A set of extreme temperature, altitude, and vibration environment test profiles were carried out following the Radio Technical Commission for Aeronautics (RTCA) DO-160 document to assess the durability and performance of the diagnostic film for onboard application. The diagnostic film was shown to be durable and reliable in withstanding the variable operational and harsh environmental conditions of tests representing the conditions of regional aircraft.