The upper Mapocho River basin, located in central Chile, has been affected by numerous landslides in the past, which may become more frequent due to a projected increase in intense precipitation events in the context of climate change. Against this background, this study aimed to analyze the ground deformation associated with an active landslide area in the Yerba Loca basin using the SBAS–DInSAR technique with PAZ and Sentinel-1 images acquired during two time periods, 2019–2021 and 2018–2022, respectively. Using PAZ imagery, the estimated vertical displacement velocity (subsidence) was as high as 9.6 mm/year between 2019 and 2021 in the area affected by the Yerba Loca multirotational slide in August 2018. Analysis of Sentinel-1 images indicated a vertical displacement velocity reaching −94 mm/year between 2018 and 2022 in the Yerba Loca landslide, suggesting continued activity in this area. It, therefore, may collapse again soon, affecting tourism services and the local ecosystem. By focusing on a mountainous region, this study demonstrates the usefulness of radar imagery for investigating landslides in remote or hard-to-reach areas, such as the mountain sector of central Chile.