Urban and regional ecosystems are increasingly challenged by the compounded effects of climate change and intensive land use. In this study, a predictive assessment framework for ecosystem resilience in the Beijing–Tianjin–Hebei region was developed by integrating multi-source remote sensing data, with the aim of quantitatively evaluating the coupled effects of climate change and land use change on future ecosystem resilience. In the first stage of the study, the SD-PLUS coupled modeling framework was employed to simulate land use patterns for the years 2030 and 2060 under three representative combinations of Shared Socioeconomic Pathways and Representative Concentration Pathways (SSP1-2.6, SSP2-4.5, and SSP5-8.5). Building upon these simulations, ecosystem resilience was comprehensively evaluated and predicted on the basis of three key attributes: resistance, adaptability, and recovery. This enabled a quantitative investigation of the spatio-temporal dynamics of ecosystem resilience under each scenario. The results reveal the following: (1) Temporally, ecosystem resilience exhibited a staged pattern of change. From 2020 to 2030, an increasing trend was observed only under the SSP1-2.6 scenario, whereas, from 2030 to 2060, resilience generally increased in all scenarios. (2) In terms of scenario comparison, ecosystem resilience typically followed a gradient pattern of SSP1-2.6 > SSP2-4.5 > SSP5-8.5. However, in 2060, a notable reversal occurred, with the highest resilience recorded under the SSP5-8.5 scenario. (3) Spatially, areas with high ecosystem resilience were primarily distributed in mountainous regions, while the southeastern plains and coastal zones consistently exhibited lower resilience levels. The results indicate that climate and land use changes jointly influence ecosystem resilience. Rainfall and temperature, as key climate drivers, not only affect land use dynamics but also play a crucial role in regulating ecosystem services and ecological processes. Under extreme scenarios such as SSP5-8.5, these factors may trigger nonlinear responses in ecosystem resilience. Meanwhile, land use restructuring further shapes resilience patterns by altering landscape configurations and recovery mechanisms. Our findings highlight the role of climate and land use in reshaping ecological structure, function, and services. This study offers scientific support for assessing and managing regional ecosystem resilience and informs adaptive urban governance in the face of future climate and land use uncertainty, promotes the sustainable development of ecosystems, and expands the applicability of remote sensing in dynamic ecological monitoring and predictive analysis.