Dr. Esen Yonca Bassoy
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Academic Career Length
17Years (2010-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications16 December 2017 in Immunological Reviews
Journal Article
31 October 2014 in Cell Death & Differentiation
Journal Article
GJG Jacquemin
G Jacquemin
DMD Margiotta
D Margiotta
AKA Kasahara
A Kasahara
Esen Yonca BassoyMWM Walch
M Walch
DMD Martinvalet
D Martinvalet +2
24 November 2017 in Nature Communications
Journal Article
PNPaula Nunes-Hasler
Paula Nunes-HaslerSMSophia Maschalidi
Sophia Maschalidi
CLCarla Lippens
Carla Lippens
CCCyril Castelbou
Cyril Castelbou
SBSamuel Bouvet
Samuel Bouvet
NDNicolas Demaurex
Nicolas Demaurex +8
Antigen cross-presentation by dendritic cells (DC) stimulates cytotoxic T cell activation to promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens generate potent T cell responses, but the signalling and trafficking pathways regulating their cross-presentation are unclear. Here, we show that ablation of the store-operated-Ca2+-entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and DC migration in vivo and in vitro.Stim1ablation reduces Ca2+signals, cross-presentation, and chemotaxis in mouse bone-marrow-derived DCs without altering cell differentiation, maturation or phagocytic capacity. Phagosomal pH homoeostasis and ROS production are unaffected by STIM1 deficiency, but phagosomal proteolysis and leucyl aminopeptidase activity, IRAP recruitment, as well as fusion of phagosomes with endosomes and lysosomes are all impaired. These data suggest that STIM1-dependent Ca2+signalling promotes the delivery of endolysosomal enzymes to phagosomes to enable efficient cross-presentation.
28 April 2020 in Life Science Alliance
Journal Article
JGJérémie D Goldstein
Jérémie D GoldsteinEsen Yonca BassoyACAssunta Caruso
Assunta Caruso
JPJennifer Palomo
Jennifer Palomo
EREmiliana Rodriguez
Emiliana Rodriguez
CGCem Gabay
Cem Gabay +1
IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36rΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r−/− mice, but acanthosis was only prevented in Il36r−/− mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration.
24 March 2017 in Cell Death & Differentiation
Journal Article
VCValentina Chiusolo
Valentina ChiusoloGJGuillaume Jacquemin
Guillaume Jacquemin
Esen Yonca BassoyLVLaurent Vinet
Laurent Vinet
LLLavinia Liguori
Lavinia Liguori
DMDenis Martinvalet
Denis Martinvalet +2
10 March 2017 in The EMBO Journal
Journal Article
Esen Yonca BassoyAKAtsuko Kasahara
Atsuko Kasahara
VCValentina Chiusolo
Valentina ChiusoloGJGuillaume Jacquemin
Guillaume Jacquemin
EBEmma Boydell
Emma Boydell
DMDenis Martinvalet
Denis Martinvalet +8
About Me
Dr. Esen Yonca Bassoy is a Research Fellow in Immuno-oncology at Mayo Clinic, Arizona, where her research focuses on identifying clinically actionable molecular targets that enhance anti-tumor immune responses in ovarian cancer. She completed her PhD in Cancer Biology and Immunology from the University of Geneva, Switzerland, in 2016, where she was awarded "Best Ph.D. thesis in 2016" by the Ph.D. school of Geneva. Her doctoral work on mitochondrial dynamics and tumor immune evasion in glioma stem-like cells was published as a cover article in The EMBO Journal (2017).
Her areas of expertise include cancer stem cell biology, tumor immune evasion mechanisms, innate and adaptive immunity, and integrated multi-omics approaches for therapeutic target discovery in immuno-oncology. At Mayo Clinic, her work focuses on tumor antigen discovery and immune signaling pathways in ovarian cancer. She has published in high-impact peer-reviewed journals and received the Outstanding Presentation prize at the 2025 Science of Medicine Grand Rounds at Mayo Clinic.