Despite significant advancesin osteoimmunology, the mechanistic underpinnings of immune–skeletal crosstalk remain insufficiently characterized, particularly at the molecular and submolecular scales. The present article introduces quantum osteoimmunology as a novel field of research exploring how quantum mechanical phenomena, such as coherence, tunneling, entanglement, and wavefunction superposition, may influence osteoimmune signaling dynamics. It argues that the current deterministic, temporally linear models of immune activation may overlook the probabilistic and non‐linear nature of molecular events governed by quantum principles. Integrating quantum principles into osteoimmune research could offer new explanatory models for unresolved questions in bone‐immune physiology and pathology. In parallel, the unique photophysical characteristics of quantum nanomaterials, such as size‐tunable emission spectra, high quantum yields, and photostability, present unprecedented opportunities for high‐resolution biomarker detection, enabling real‐time, ultrasensitive diagnostics for osteoimmune pathologies. Moreover, these materials exhibit significant potential for the development of traceable, precision‐targeted therapeutic delivery systems, as well as for high‐resolution in vitro and in vivo bioimaging applications. Ultimately, quantum mechanics holds the potential to revolutionize osteoimmunology—conceptually, by reshaping one's understanding of immune–skeletal interactions at the subatomic level; and practically, by driving innovations in diagnostics, targeted therapeutics, and real‐time molecular imaging.

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to serious systemic complications. Its clinical presentation varies widely, ranging from mild, self-limiting symptoms to severe, life-threatening illness. Currently, there are no specific therapies approved for the treatment of AP, and management primarily relies on supportive care. However, a growing number of clinical trials have evaluated the translational potential of effective therapies derived from experimental models and have identified promising pharmacological agents that may help ameliorate disease severity. Alongside pharmacological approaches, nutritional management of AP has been gaining increasing attention. Evidence supports the use of enteral nutrition over parenteral feeding, as it is associated with a lower risk of necrotic infections, multiple organ dysfunction, mortality, and other associated complications of AP. In this review, we summarize the therapeutic potential of pharmacological and dietary/nutritional interventions, including naturally occurring bioactive compounds, for AP in the context of its molecular pathology, with the aim of supporting improved clinical decision-making, enhancing patient outcomes, and informing future research directions.

Preclinical surgical studies in rodent models play a pivotal role in elucidating the mechanisms of bone repair and regeneration. Similar to clinical practice, intraoperative and postoperative complications in preclinical studies significantly affect treatment outcomes and may even alter the overall experimental results. Well-established laboratory infrastructure and experimental procedures can reduce the risk of adverse events, such as intraoperative technical errors and postoperative infection. However, these aspects are often underreported or overlooked in the literature. In this study, fracture fixation in rats is presented as an example to highlight the essential but often unreported details, such as virtual surgical planning, preoperative rehearsal, disinfection protocols, intraoperative management, postoperative support, multidisciplinary collaboration, and research documentation. Supplementary and alternative solutions are also proposed for laboratories with limited resources. By applying virtual planning and rehearsal with three-dimensional (3D)-printed samples, the authors have performed 108 consecutive external fixation procedures for rat femoral fractures since 2020, with no intraoperative dropouts attributable to surgical technique errors. The operative time stabilized at 45.6 ± 3.8 minutes (mean ± standard deviation), reflecting low variability and a reproducible workflow. Systematic implementation of these strategies helps prevent postoperative complications, enhances animal welfare, and improves the reproducibility and translational potential of preclinical research.

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to serious systemic complications. Its clinical presentation varies widely, ranging from mild, self-limiting symptoms to severe, life-threatening illness. Currently, there are no specific therapies approved for the treatment of AP, and management primarily relies on supportive care. However, a growing number of clinical trials have evaluated the translational potential of effective therapies derived from experimental models and have identified promising pharmacological agents that may help ameliorate disease severity. Alongside pharmacological approaches, nutritional management of AP has been gaining increasing attention. Evidence supports the use of enteral nutrition over parenteral feeding, as it is associated with a lower risk of necrotic infections, multiple organ dysfunction, mortality, and other associated complications of AP. In this review, we summarize the therapeutic potential of pharmacological and dietary/nutritional interventions for AP in the context of its molecular pathology, with the aim of sup-porting improved clinical decision-making, enhancing patient outcomes, and inform-ing future research directions.