Patients with hepatocellular carcinoma who underwent radiation segmentectomy with yttrium 90 resin microspheres received a median tumor absorbed dose of 232 Gy, and 88% showed a per-lesion duration of response of 1 year or greater.

The imbalance between organ supply and demand continues to limit the broader benefits of organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by expanding the use of extended criteria donors (ECDs). Using the UNOS/OPTN STAR dataset we reviewed the effect of MP implementation on the behavior of transplant centers. We identified 15 high-utilizing MP centers that were matched to suitable controls based on volume and geographical proximity. We conducted a Differences-in-Differences analysis using linear regression to estimate the impact of MP adoption on the transplant centers' donor utilization. We found a significant increase in cold ischemia time and organs with donor warm ischemia time (DWIT) over 30 minutes (p < 0.05). After removing one outlier center, the analysis showed that these centers through MP accepted overall more DCD donors, DCD donors over 50 years old, donors with macrovesicular steatosis greater than 30% on liver biopsy and with DWIT over 30 minutes (p < 0.05). MP has allowed centers to expand their use of ECDs beyond traditional cutoffs and to increase patient access to liver transplantation.

Long-Term Outcomes of Early Experience in Donation After Circulatory Death Liver Transplantation: Outcomes at 10 Years - Article abstract #930243