⁹⁰Y radioembolization (selective internal radiation therapy [SIRT]) is a valuable therapeutic option for unresectable hepatic metastases arising from primary colorectal cancer. The present study evaluated the prognostic value of ¹⁸F-FDG PET/CT metabolic parameters for predicting survival after SIRT. Methods: Eighty patients with hepatic metastases of colorectal cancer were treated with SIRT. ¹⁸F-FDG PET/CT was performed at baseline and 3 mo after the treatment. Metabolic volume, total lesion glycolysis, and maximum and peak standardized uptake value (SUV_max and SUV_peak, respectively) according to PET Response Criteria in Solid Tumors (PERCIST 1.0) were obtained from 3 liver lesions in each patient, and the corresponding percentage changes from baseline to follow-up were calculated. Tumor response was defined as more than a 30% decrease in these parameters. Furthermore, response was evaluated in accordance with Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Toxicity events and survival were recorded. Results: Overall median survival after SIRT was 60 wk. Responders who had a change in metabolic volume or total lesion glycolysis had significantly longer survival (92 vs. 49 wk [P = 0.006] and 91 vs. 48 wk [P = 0.025], respectively). However, neither RECIST 1.1 criteria nor changes in SUV_peak or SUV_max after treatment predicted outcome (P = 0.086 for RECIST; P = 0.310 for change in SUV_peak; P = 0.155 for change in SUV_max). Conclusion: Changes in metabolic volume and total lesion glycolytic rate as measured by ¹⁸F-FDG PET predicted survival in patients with hepatic metastases from colorectal cancer, whereas changes in SUV_peak or SUV_max and RECIST 1.1 criteria did not predict survival.

This study investigated the influence of solid particles on primary breakup and resulting droplet size for different process parameters. Two sets of Newtonian fluids (each consisting of one pure liquid and one suspension at the same respective viscosity) were used, for isolated investigation of solid particles on spray formation independent of liquid viscosity. The spray was recorded by a high-speed camera and a SpraySpy^® system based on the time-shift effect, while a commonly used Spraytec^® laser diffraction analyzer was employed for validation. An external-mixing twin-fluid atomizer was operated at different gas velocities and corresponding GLR at constant liquid mass flow. For the investigated suspensions an increased Sauter mean diameter was detected, compared to the pure liquids with identical dynamic viscosity. This effect was explained by the tensile strength stabilizing the suspension droplets.