Research on dolomite has long been central in geoscience, yet understanding the origin of Middle Ordovician dolomite in the northeast of the North China Platform remains limited. Based on this, this study focuses on dolomite of Majiagou Formation in Liujiang Basin, and analyzes its genetic process. The research is based on the measured geological section and conducts high-precision analysis and testing, encompassing major and trace elements, rare earth elements, stable carbon and oxygen isotopes, strontium isotopes, crystal structure parameters, and micro-area elements of dolomite. Analysis of V/(V + Ni), Th/U, Sr/Ba, Mn/Sr, (Eu/Eu*) _N, (Ce/Ce*) _N, and the dolomite crystal parameters indicates that the formation of dolomite is related to evaporation. Furthermore, REE and micro-area characteristics of dolomite, as well as the significant negative deviation of δ¹³C and δ¹⁸O, in conjunction with ⁸⁷Sr/⁸⁶Sr deviating from the standard values of Ordovician seawater, suggest an origin of the dolomite in this formation with mixed-water dolomitization and burial dolomitization. A comprehensive assessment of dolomite formation suggests three distinct stages: early-stage evaporation dolomitization, subsequent mixed-water dolomitization, and later-stage burial dolomitization. The research further corroborated that dolomite formation is a complex outcome resulting from the interplay of various geological processes over space and time.