Background: Quantum computing is a rapidly growing new programming paradigm that brings significant changes to the design and implementation of algorithms. Understanding quantum algorithms requires knowledge of physics and mathematics, which can be challenging for software developers. Aims: In this work, we provide a first analysis of how LLMs can support developers’ understanding of quantum code. Method: We empirically analyse and compare the quality of explanations provided by three widely adopted LLMs (Gpt3.5, Llama2, and Tinyllama) using two different human-written prompt styles for seven state-of-the-art quantum algorithms. We also analyse how consistent LLM explanations are over multiple rounds and how LLMs can improve existing descriptions of quantum algorithms. Results: Llama2 provides the highest quality explanations from scratch, while Gpt3.5 emerged as the LLM best suited to improve existing explanations. In addition, we show that adding a small amount of context to the prompt significantly improves the quality of explanations. Finally, we observe how explanations are qualitatively and syntactically consistent over multiple rounds. Conclusions: This work highlights promising results, and opens challenges for future research in the field of LLMs for quantum code explanation. Future work includes refining the methods through prompt optimisation and parsing of quantum code explanations, as well as carrying out a systematic assessment of the quality of explanations.

ML systems have become an essential tool for experts of many domains, data scientists and researchers, allowing them to find answers to many complex business questions starting from raw datasets. Nevertheless, the development of ML systems able to satisfy the stakeholders’ needs requires an appropriate amount of knowledge about the ML domain. Over the years, several solutions have been proposed to automate the development of ML systems. However, an approach taking into account the new quality concerns needed by ML systems (like fairness, interpretability, privacy, and others) is still missing.In this paper, we propose a new engineering approach for the quality-based development of ML systems by realizing a workflow formalized as a Software Product Line through Extended Feature Models to generate an ML System satisfying the required quality constraints. The proposed approach leverages an experimental environment that applies all the settings to enhance a given Quality Attribute, and selects the best one. The experimental environment is general and can be used for future quality methods’ evaluations. Finally, we demonstrate the usefulness of our approach in the context of multi-class classification problem and fairness quality attribute.

Multiple sclerosis (MS) is a complex, chronic, and heterogeneous disease of the central nervous system that affects 3 million people globally. The multifactorial nature of MS necessitates an adaptive and personalized approach to diagnosis, monitoring, and treatment. This paper proposes a novel Digital Twin for Multiple Sclerosis (DTMS) designed to integrate diverse data sources, including Magnetic resonance imaging (MRI), clinical biomarkers, and digital health metrics, into a unified predictive model. The DTMS aims to enhance the precision of MS management by providing real-time, individualized insights into disease progression and treatment efficacy. Through a federated learning approach, the DTMS leverages explainable AI to offer reliable and personalized therapeutic recommendations, ultimately striving to delay disability and improve patient outcomes. This comprehensive digital framework represents a significant advancement in the application of AI and digital twins in the field of neurology, promising a more tailored and effective management strategy for MS.