Background: Pneumonectomy is a major surgical option for non-small cell lung cancer (NSCLC). This study evaluates the predictive value of three-dimensional computed tomography (3D-CT)-based lung volume analysis for postoperative function and explores its potential role in preoperative planning, risk assessment, and surgical decision-making. Methods: We evaluated 59 NSCLC patients who underwent pneumonectomy. Pre- and 12-month postoperative spirometry results were compared with anatomical and 3D-CT-based predictions. Residual lung expansion was calculated, and patients were grouped by a 3D-CT-derived volume ratio of ≥1.2 or <1.2. Results: There was a significant correlation between 3D-CT-based predicted FVC and FEV1 and postoperative spirometric values (p < 0.001). The mean residual lung volume expansion ratio was 1.23. Patients with a ratio ≥1.2 had significantly higher postoperative FVC (p = 0.028). Lung expansion was observed in 81.4% of cases. Predicted postoperative FVC (p = 0.023) and FEV1 (p = 0.013) were significantly higher in patients with left pneumonectomy compared to right. Conclusions: 3D-CT-based lung volume calculation reliably predicts postoperative function and matches conventional methods. Contralateral lung expansion positively affects respiratory outcomes. Additionally, 3D-CT analysis supports preoperative planning and risk assessment, contributing to more accurate diagnosis and surgical decisions in NSCLC management.

COVID-19 is a disease that primarily affects the lungs and may follow a fatal course. The aim of this study was to investigate whether there are difference

Background: Kisspeptins, neuropeptides encoded by the KISS1 gene, play a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis and have emerging links to metabolic regulation, energy balance, and feeding behaviour. The precise mechanisms by which kisspeptin influences key metabolic peptides such as leptin, ghrelin, and orexin-A remain unclear. This study investigates the metabolic effects of kisspeptin, exploring its interactions with stress-related neuropeptides, including corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), oxytocin, and vasopressin. Methods: Rats were randomly divided into seven groups (n = 10 per group): Sham (control), Kisspeptin (50 pmol), P234 (1 nmol), Kisspeptin + p234 (1 nmol), Kisspeptin + Antalarmin (0.1 μg), Kisspeptin + astressin-2B (1 μg), and Kisspeptin + Atosiban (300 ng). All treatments were administered via intracerebroventricular (ICV) injection. Rats were anesthetized with urethane (1.25 g/kg, i.p.). Serum was collected by decapitation after 30 minutes, and levels of orexin-A, ghrelin and leptin were measured using commercial ELISA kits. Results: Kisspeptin administration alone did not significantly affect plasma leptin levels (p > 0.05). However, kisspeptin significantly reduced serum ghrelin levels (40% reduction) (p < 0.05). Co-administration of kisspeptin with p234 (1100 pg/ml), antalarmin (1400 pg/ml), astressin-2B (1050 pg/ml), or atosiban (900 pg/ml) resulted in elevated ghrelin levels (p