Cadmium (Cd) contamination has become serious in soil and in situ stabilization technology has been widely used for heavy metal remediation. A field study was conducted to determine the effect of amendments with the doses of 3 kg/m2, including single vermicompost (A1), a 95% vermicompost mixed with 5% shell powder composite (A2) and a 95% vermicompost mixed with 5% modified shell powder composite (A3), on the Cd bioavailability, enzyme activity and bacterial community in soil, and the experiment was conducted with lettuce (Lactuca sativa L.) grown in a Cd-contaminated farmland soil. The results showed that the application of amendments increased the pH, cation exchange capacity (CEC), organic matter (OM), available nutrients, catalase (S-CAT), invertase (S-SC) and urease (S-UE) activities in soil, while significantly reduced the Cd bioavailability with the lowest Cd bioavailability being observed in the soil with A3 application. The soil bacterial richness and diversity increased after amendments application, and the bacterial community was characterized by an increase in metal-tolerant bacteria but a decrease in Proteobacteria, Acidobacteria and Gemmatimonadetes. In addition, the application of amendments significantly improved the growth of lettuce (Lactuca sativa L.) and inhibited Cd accumulation in its edible parts, especially, the Cd content in lettuce (Lactuca sativa L.) grown in soil with A3 application was below the limit of the National Food Safety Standard of China (maximum level ≤ 0.2 mg/kg). Thus, composite amendment obtained from vermicompost mixed with modified shell powder can be used as potential remediation material in Cd-contaminated soil. CAPSULE: Composite amendment obtained from vermicompost and modified shell powder had good effects on remediation of Cd-contaminated soil.