BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care needs. Protecting the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal cancer. However, the ileostomy is susceptible to peri-stoma skin complications, as well as fluid, electrolyte, and nutritional imbalances, posing challenges to effective management. The successful self-management of patients is intricately linked to their adjustment to temporary colostomy; nonetheless, there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they confront. AIM To investigate the lived experiences, perceptions, and care requirements of temporary colostomy patients within their home environment, with the ultimate goal of formulating a standardized management protocol. METHODS Over the period of June to August 2023, a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai, China. Employing a phenomenological research approach, a semi-structured interview guide was developed, and qualitative interviews were conducted using in-depth interview techniques. The acquired data underwent coding, analysis, organization, and summarization following Colaizzi’s seven-step method. RESULTS The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes: Firstly, Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression; secondly, patients exhibit limited self-care capabilities and face information deficits, resulting in heightened reliance on healthcare professionals; thirdly, patients demonstrate the potential for internal motivation through proactive self-adjustment; and finally, patients express a significant need for emotional and social support. CONCLUSION Home-living patients with temporary intestinal stomas confront multifaceted challenges encompassing burdens, inadequate self-care abilities, informational deficits, and emotional needs. Identifying factors influencing patients’ self-care at home and proposing strategies to mitigate barriers can serve as a foundational framework for developing and implementing nursing interventions tailored to the needs of patients with temporary intestinal stomas.

Background Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder, affecting over 8.5 million people worldwide, with symptoms that severely impact patients’ quality of life. While treatments like levodopa and deep brain stimulation help manage symptoms, they require frequent adjustments and have limitations. Wearable devices offer real-time monitoring of motor and non-motor symptoms, enabling personalized treatment, but challenges related to comfort, usability, and patient adherence hinder their widespread adoption. Many individuals with PD experience discomfort, emotional distress, or interface difficulties, reducing long-term adherence. This study synthesizes qualitative research on patients’ experiences with wearables to identify key usability barriers and improve device design for better clinical integration. Methods Following the Joanna Briggs Institute methodology for qualitative systematic reviews, we searched PubMed, Web of Science, Embase, Cochrane Library, CINAHL, CNKI, WanFang, and VIP databases up to March 3, 2025. Additional gray literature and reference lists were examined manually. Included qualitative studies underwent comprehensive assessment, integration, and analysis. Results Nine studies were included, identifying four main themes and eleven sub-themes. The four primary themes were physiological experience, psychological Responses, social Interaction, and Expectation. Conclusion This meta-synthesis reveals the dual role of wearable devices in managing Parkinson’s disease, improving patient autonomy and disease control while presenting challenges in comfort, reliability, and emotional well-being. The findings emphasize the need for personalized, context-sensitive devices that adapt to fluctuating PD symptoms, address privacy concerns, and seamlessly integrate into clinical practice to improve clinical outcomes and patient adherence.

Congenital heart disease (CHD) is the most common birth defect, affecting approximately 1% of live births. Genetic and environmental factors are leading factors to CHD, but the mechanism of CHD pathogenesis remains unclear. Circular RNAs (circRNAs) are kinds of endogenous non‐coding RNAs (ncRNAs) involved in a variety of physiological and pathological processes, especially in heart diseases. In this study, three significant differently expressed circRNA between maternal embryonic day (E) E13 and E17 was found by microarray assay. Among them, the content of circ‐RCCD increases with the development of heart and was enriched in primary cardiomyocytes of different species, which arouses our attention. Functional experiments revealed that inhibition of circ‐RCCD dramatically suppressed the formation of beating cell clusters, the fluorescence intensity of cardiac differentiation marker MF20, and the expression of the myocardial‐specific markers CTnT, Mef2c, and GATA4. Next, we found that circ‐RCCD was involved in cardiomyocyte differentiation through negative regulation of MyD88 expression. Further experiments proved that circ‐RCCD inhibited MyD88 levels by recruiting YY1 to the promoter of MyD88; circ‐RCCD inhibited nuclear translocation of YY1. These results reported that circ‐RCCD promoted cardiomyocyte differentiation by recruiting YY1 to the promoter of MyD88. And, this study provided a potential role and molecular mechanism of circ‐RCCD as a target for the treatment of CHD.

BACKGROUND This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking. AIM To investigate anesthetic nurses’ cognition and management experiences of ED in hopes of developing a standardized management protocol. METHODS This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research subjects. Semi-structured interviews were conducted, and the data were organized and analyzed using Colaizzi’s seven-step analysis method, from which the final themes were extracted. RESULTS After analyzing the interview content, four main themes and eight subthemes were distilled: Inefficient cognition hinders the identification of ED (conceptual ambiguity, empirical identification), managing diversity and challenges (patient-centered safe care, low level of medical-nursing collaboration), work responsibilities and pressure coexist (heavy work responsibilities, occupational risks and stress), demand for high-quality management (expecting the construction of predictive assessment tools and prevention strategies, and pursuing standardized management processes to enhance management effectiveness). CONCLUSION Nursing managers should prioritize the needs and suggestions of nurses in order to enhance their nursing capabilities and provide guidance for standardized management processes.

BACKGROUND The bowel preparation process prior to colonoscopy determines the quality of the bowel preparation, which in turn affects the quality of the colonoscopy. Colonoscopy is an essential procedure for postoperative follow-up monitoring of colorectal cancer (CRC) patients. Previous studies have shown that advanced age and a history of colorectal resection are both risk factors for inadequate bowel preparation. However, little attention has been paid to the bowel preparation experiences and needs of predominantly older adult postoperative CRC patients. AIM To explore the experiences and needs of older adult postoperative CRC patients during bowel preparation for follow-up colonoscopy. METHODS Fifteen older adult postoperative CRC patients who underwent follow-up colonoscopy at a tertiary hospital in Shanghai were selected using purposive sampling from August 2023 to November 2023. The phenomenological method in qualitative research was employed to construct an interview outline and conduct semi-structured interviews with the patients. Colaizzi's seven-step analysis was utilized to organize, code, categorize, summarize, and verify the interview data. RESULTS The results of this study were summarized into four themes and eight sub-themes: (1) Inadequate knowledge about bowel preparation; (2) Decreased physiological comfort during bowel preparation (gastrointestinal discomfort and sleep deprivation caused by bowel cleansing agents, and hunger caused by dietary restrictions; (3) Psychological changes during different stages of bowel preparation (pre-preparation: Fear and resistance due to previous experiences; during preparation: Irritation and helplessness caused by taking bowel cleansing agents, and post-preparation: Anxiety and worry while waiting for the colonoscopy); and (4) Needs related to bowel preparation (detailed instructions from healthcare professionals; more ideal bowel cleansing agents; and shortened waiting times for colonoscopy). CONCLUSION Older adult postoperative CRC patients' knowledge of bowel preparation is not adequate, and they may encounter numerous difficulties and challenges during the process. Healthcare professionals should place great emphasis on providing instruction for their bowel preparation.

Aim: This study aims to explore the life experiences and health behavior management experiences of elderly patients with dry eye disease, and to provide a reference for improving the health status of patients with dry eye disease. Methods: A qualitative phenomenological design was employed to collect data from 16 dry eye patients who visited the eye clinic of a tertiary hospital in Shanghai, China, from October to December 2024, by conducting face-to-face semi-structured interviews, and analyzing the data using the Colaizzi 7-step analysis method. Interviews were transcribed verbatim, and themes were coded and extracted using NVivo 14.0. Results: The participants, aged between 60 and 78 years, mostly had mild to moderate levels of dry eye. Based on the theoretical model of the Health Belief Model, five main themes and eleven sub-themes were summarized from the analysis: (a) Perceived threat of disease (Perceived severity, Perceived susceptibility); (b) Perceived benefits (Perceived sense of gain, Improved quality of life); (c) Perceived barriers (Lack of willingness to manage behavior, Insufficient intrinsic motivation, Cognitive misconceptions); (d) Low self-efficacy (Lack of confidence in responding, Negative coping style); (e) Perception of behavioral cues (Lack of external support, Perception of self-management). Conclusion: This study found an interaction between reduced threat perception and inadequate health behavior management in elderly dry eye patients, and future research is needed to develop more specific and feasible intervention programs to encourage patients to move from passive treatment to active management.