The paper presents the study results obtained for the reactive interaction and the wetting contact angle when a titanium melt comes into contact with the surface of a calcium ti-tanate substrate. It is shown that the wetting contact angle decreases from 93 to 74° with an increase in the contact temperature of the melt with the CaTiO3 substrate from 1670 to 1728 °C. As the isothermal holding time increases at 1705°C, the wetting contact angle in-creases, and at 1720°C, the wetting contact angle gradually decreases. The processes oc-curring at the interface of the solid and liquid phases are described. It is shown that when titanium comes into contact with CaTiO3, the following processes develop: penetration of titanium melt through capillaries between CaTiO3 particles; dissolution of CaTiO3 in the melt; reduction of calcium to a metallic state and its evaporation with the formation of a vapor layer between the substrate and the melt; diffusion of oxygen into the melt and its binding into a TiO compound that forms a shell on the melt surface. Due to the dissolu-tion of CaTiO3 in the titanium boundary layer and a decrease in the concentration of Ca, a melt is formed after crystallization of which the eutectic CaTiO3+αTi(Ca,O) is formed. The most likely cause of the large wetting contact angle of the CaTiO3 surface by titanium melt is the formation of a vapor layer at the interface between the solid and liquid phases. The found features of the CaTiO3 interaction with titanium melt made it possible to recom-mend it as the basis of molding materials for casting molds intended for the production of castings from titanium alloys.