As a degradable natural biomaterial, gelatin has good biocompatibility and nontoxicity, but gelatin is easily soluble in water which has limited its application. In order to solve this tough defect, superhydrophobic gelatin films (GSF) were prepared by first grafting silica nanoparticles onto gelatin films and then modifying silica nanoparticles with a fluorosilane coupling agent (FAS). Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), a particle size analyzer, a contact angle instrument (CA), X-ray photoelectron spectroscopy (XPS), a universal materials tester and an Incucyte™ Zoom system were used to characterize the morphology, molecular interactions, superhydrophobic performance, and cytotoxicity. Results show that GSF₃₀₀ modified by silica nanoparticles with a particle size of 303 nm has the largest contact angle (158.6°). At the same time, the contact angle is still more than 150° after 48 hours of infiltration in water. These results indicate that GSF₃₀₀ has strong long-term water resistance. In addition, GSF₃₀₀ has good mechanical strength, durability and nontoxicity. Therefore, such a durable, robust and superhydrophobic film has good potential applications in various functional biomedical aspects.

In this paper, environmentally friendly gelatin/β-cyclodextrin (β-CD) composite fiber adsorbents prepared by electrospinning were used for the removal of dyes from wastewater. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and a universal materials tester were employed to characterize the internal structures, surface morphologies and mechanical strength of the composite fiber adsorbents. Additionally, the fiber was evaluated as an adsorbent for the removal of methylene blue (MB) from aqueous solution. The effects of the raw material ratio, pH, temperature, concentration and adsorption time were studied. The results show that the gelatin/β-CD composite fiber adsorbents possess excellent mechanical strength and high adsorption efficiency for MB. The adsorption equilibrium and adsorption kinetics are well-described by the Langmuir isotherm model and the pseudo-second-order kinetic model, respectively. The theoretical maximum adsorption capacity is 47.4 mg·g⁻¹. Additionally, after nine successive desorption-adsorption cycles, the removal rate is still over 70%. Moreover, the gelatin/β-CD composite fiber adsorbents exhibit excellent adsorption capability for basic fuchsin, gentian violet, brilliant blue R and malachite green dyes. Therefore, owing to the characteristics of degradability, low cost and high-efficiency, the gelatin/β-CD composite fiber can be used as an efficient adsorbent for the removal of dyes from wastewater.

Traditional wound dressings require frequent replacement, are prone to bacterial growth and cause a lot of environmental pollution. Therefore, biodegradable and antibacterial dressings are eagerly desired. In this paper, gelatin/ZnO fibers were first prepared by side-by-side electrospinning for potential wound dressing materials. The morphology, composition, cytotoxicity and antibacterial activity were characterized by using Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), particle size analyzer (DLS), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetry (TGA) and Incucyte™ Zoom system. The results show that ZnO particles are uniformly dispersed on the surface of gelatin fibers and have no cytotoxicity. In addition, the gelatin/ZnO fibers exhibit excellent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) with a significant reduction of bacteria to more than 90%. Therefore, such a biodegradable, nontoxic and antibacterial fiber has excellent application prospects in wound dressing.

Ionic hydrogels have great application potential in human index monitoring and wound treatment, such as in wearable sensors, wound dressings, and ionic skin. However, the design of a hydrogel achieving the synergistic characteristics of excellent mechanical properties, robust adhesion, and multiple stimuli-responses remains a critical challenge. Herein, by introducing negatively charged clay nanosheets, we report a smart ionic Gelatin/PAAm/Clay hydrogel (GPNs gel) with a high conductivity of 10.87 mS cm⁻¹. The as-prepared gel exhibits excellent self-healing properties, robust adhesion (interfacial toughness of up to 485 J m⁻² with pigskin), and multiple stimuli-responses driven by salt ions, pH, and stress. Based on this hydrogel, a capacitive sensor has also been designed, which provides linear responses over a wide range (applied pressure up to 2 kPa) and sensitively monitors human motion. In addition, the gel also displays good biocompatibility with human lung embryonic (MRC-5) cells. These characteristics demonstrate that the GPNs gel is an ideal candidate for developing flexible sensor devices.

Conductive hydrogels have attracted increasing attention because of their important application in flexible pressure sensors. However, designing hydrogels with a combination of excellent mechanical properties, high sensitivity, and good biocompatibility is still a profound challenge. Here we report a conductive and biocompatible PVA–Gelatin–nHAP hydrogel (PGHAP gel) by connecting a double network with inorganic nano-particles via ionic bonds. The as-prepared gel achieves excellent elasticity and good fatigue resistance even after 50 cycles of compression. Then a hydrogel pressure sensor was obtained using the as-prepared gel, exhibiting high pressure sensitivity almost linearly responding up to 1.5 kPa and adequate stability of the capacitance–pressure over 4 cycles. These results demonstrate the great potential applications of the hydrogel in biomedical devices, including artificial intelligence, human motion detection, and wearable devices.