Dr. Vitor H Pomin
School of Pharmacy, Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississippi, USA
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Academic Career Length
19Years (2008-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications29 August 2008 in Glycobiology
Journal Article
Vitor H PominPMPaulo A S Mourão
Paulo A S Mourão
Sulfated fucans and galactans are strongly anionic polysaccharides found in marine organisms. Their structures vary among species, but their major features are conserved among phyla. Sulfated fucans are found in marine brown algae and echinoderms, whereas sulfated galactans occur in red and green algae, marine angiosperms, tunicates (ascidians), and sea urchins. Polysaccharides with 3-linked, β-galactose units are highly conserved in some taxonomic groups of marine organisms and show a strong tendency toward 4-sulfation in algae and marine angiosperms, and 2-sulfation in invertebrates. Marine algae mainly express sulfated polysaccharides with complex, heterogeneous structures, whereas marine invertebrates synthesize sulfated fucans and sulfated galactans with regular repetitive structures. These polysaccharides are structural components of the extracellular matrix. Sulfated fucans and galactans are involved in sea urchin fertilization acting as species-specific inducers of the sperm acrosome reaction. Because of this function the structural evolution of sulfated fucans could be a component in the speciation process. The algal and invertebrate polysaccharides are also potent anticoagulant agents of mammalian blood and represent a potential source of compounds for antithrombotic therapies.
Journal Article
Vitor H PominBMBarbara Mulloy
Barbara MulloyIn this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix proteoglycans, like aggrecan, perlecan, and small leucine-rich proteoglycans. The context in which the pharmaceutical uses of glycosaminoglycans and proteoglycans are presented in this special issue is given at the very end.
Journal Article
Vitor H PominFucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates. However, FucCS has also sulfated fucosyl branching units 3-O-linked to the acid residues. The sulfation patterns of these branches vary accordingly with holothurian species and account for different biological actions and responses. FucCSs may exhibit anticoagulant, antithrombotic, anti-inflammatory, anticancer, antiviral, and pro-angiogenic activities, besides its beneficial effects in hemodialysis, cellular growth modulation, fibrosis and hyperglycemia. Through an historical overview, this document covers most of the science regarding the holothurian FucCS. Both structural and medical properties of this unique GAG, investigated during the last 25 years, are systematically discussed herein.
1 January 2015 in International Journal of Biological Macromolecules
Journal Article
Vitor H PominAbout Me
Dr. Vitor H. Pomin is an Assistant Professor of Pharmacognosy and Assistant Research Professor at the Research Institute of Pharmaceutical Sciences of the University of Mississippi. He pursued his undergraduate course at the Institute of Biological Sciences, Federal University of Rio de Janeiro (UFRJ), Brazil, and graduate studies in Biological Chemistry at the Institute of Medical Biochemistry Leopoldo de Meis (IBqM), UFRJ. He received his Diploma of Licentiate, M.S., and Ph.D. in 2003, 2005, and 2008, respectively, all from UFRJ. After completing his Ph.D., he pursued a post-doctorate at the Complex Carbohydrate Research Center, University of Georgia, until 2011. After this time and prior to joining the University of Mississippi, he was an Assistant professor of Biological Chemistry, Biochemistry, Glycobiology, and NMR Spectroscopy (IBqM/UFRJ). He has over 110 published articles in peer-reviewed journals and has served as the main editor for six academic/scientific books. He currently serves as an editorial member and frequent ad hoc reviewer of many internationally recognized journals, like the Journal of Biological Chemistry, Chemical Reviews, Carbohydrate Polymers, Carbohydrate Research, Marine Drugs, Analytical Chemistry, Glycobiology, Journal of Natural Products, PLoS ONE, European Journal of Medicinal Chemistry, and many others. He conducts research on glycobiology (mostly sulfated polysaccharides), structural (glyco)biology, and NMR spectroscopy.