Background: Sarcopenia significantly affects the health and quality of life in older adults. Exercise combined with nutritional interventions is widely recognized as an effective strategy for improving sarcopenia outcomes. However, current studies rarely focus on differential effects across subpopulations with distinct demographic and health characteristics. This study aimed to explore the effects of combined exercise and nutrition interventions on sarcopenia-related outcomes, considering the variations in population characteristics. Methods: A systematic search was conducted across PubMed, Embase, the Web of Science, and Cochrane Library, covering the literature published between January 2010 and March 2025. Only randomized controlled trials (RCTs) evaluating combined exercise and nutritional interventions for sarcopenia were included. The primary outcomes were handgrip strength (HS), the skeletal muscle mass index (SMI), gait speed (GS), and the five-times sit-to-stand test (5STS). The mean differences (MD) with 95% confidence intervals (CIs) were calculated. Random-effects models were used for the meta-analysis and subgroup comparisons. Results: Fifteen RCTs involving 1258 participants in the intervention group and 1233 in the control group were included. Exercise combined with nutritional interventions significantly improved sarcopenia-related outcomes. HS improved with a pooled MD of 1.77 kg (95% CI: 0.51 to 3.03, p = 0.006); SMI increased by 0.22 kg/m² (95% CI: 0.09 to 0.35, p = 0.0007); GS improved by 0.09 m/s (95% CI: 0.04 to 0.14, p = 0.0002); and 5STS performance improved with a time reduction of −1.38 s (95% CI: −2.47 to −0.28, p = 0.01). Subgroup analyses indicated that the intervention effects varied according to age, BMI, and living environment. Conclusions: Exercise combined with nutrition is effective in improving key outcomes associated with sarcopenia in older adults. The magnitude of these effects differed across population subgroups, underscoring the importance of tailoring interventions to specific demographic and health profiles.

Background: Exercise is increasingly recognized as a non-pharmacological strategy for cognitive aging; however, comparative evidence across modalities, phenotypes, and doses is limited. Methods: We conducted a Bayesian network meta-analysis of 38 randomized controlled trials ( N = 4,047; 88 arms). The interventions included aerobic, resistance, multimodal, and other exercise formats compared with non-exercise controls. The primary outcome was global cognition. Analyses were stratified by age (< 70 vs. ≥70 years) and phenotype (healthy vs. pre-sarcopenic). Dose–response relationships were modeled using the weekly volume (MET·min/week). Results: Aerobic (standardized mean difference [SMD] 0.58, 95% CI 0.33–0.83), resistance (0.62, 0.35–0.88), and multimodal programs (0.68, 0.40–0.95) significantly improved cognition compared to the control, with smaller effect sizes. Healthy older adults benefited most from aerobic (0.88, 0.55–1.20) and resistance training (0.80, 0.42–1.19), whereas multimodal programs were most effective for pre-sarcopenia (0.60, 0.29–0.90). Dose–response analysis showed clinically meaningful benefits from ~ 600 MET·min/week, with optimal effects between 700 and 1,200 MET·min/week. Higher volumes conferred no consistent additional gains in pre-sarcopenia. Conclusions: Exercise is a scalable, safe, and clinically effective approach for preserving late-life cognition. For healthy older adults, aerobic or resistance training at ≥ 600 MET·min/week is recommended; for pre-sarcopenic individuals, multimodal programs at approximately 700–800 MET·min/week offer the best balance of efficacy and sustainability. These findings provide actionable targets for clinicians and policymakers, advancing precision exercise prescriptions for cognitive health in aging populations.

Background: Muscle health decline is a major concern in postmenopausal women; however, most interventions have focused on exercise as an isolated component. It remains unclear whether embedding exercise within a broader lifestyle framework enhances muscle-related outcomes. Methods: A total of 100 postmenopausal women took part in this randomized controlled trial and were randomly assigned to three groups: Nordic walking combined with high-protein intake and time-restricted eating (NW+HP+TRE, n = 36), Nordic walking combined with time-restricted eating (NW+TRE, n = 33), and a control group (n = 31). The intervention lasted 12 weeks. The primary outcome was handgrip strength, and the secondary outcomes included physical performance (6 m gait speed and five times chair-stand time) and lean mass-related measures. Adherence to all intervention components was monitored throughout the study. Results: During the intervention, four participants did not complete the post-intervention assessment, resulting in 96 participants being included in the final analysis. Handgrip strength improved in both intervention groups, with the largest increase observed in the NW+HP+TRE group. Physical performance outcomes showed a similar pattern. In contrast, the NW+TRE group showed less favorable changes in lean mass-related measures, whereas the control group showed minimal overall changes. Adherence to Nordic walking, time-restricted eating, and protein intake was high in the intervention groups. Conclusions: A Nordic walking-based integrated lifestyle intervention was associated with a more favorable overall pattern of change in muscle strength, physical performance, and lean mass-related outcomes in postmenopausal women. These findings should be interpreted as differences between intervention packages rather than as evidence for the isolated effect of any single lifestyle component. Further research is needed to examine the long-term sustainability of such interventions and to clarify the contribution of individual components.