Background: Increasing evidence suggests a close association between the intestinal microbiome and the respiratory system, drawing attention to studying the gut-lung axis. This research employs bibliometric methods to conduct a visual analysis of literature in the field of intestinal microbiota and lung diseases over the past two decades. It offers scientific foundations for research directions and critical issues in this field.Methods: We retrieved all articles on intestinal microbiota and lung diseases from the SCI-Expanded of WoSCC on October 25, 2023. The analysis included original articles and reviews published in English from 2011 to 2023. We utilized Python, VOSviewer, and CiteSpace to analyze the retrieved data visually.Results: A total of 794 publications were analyzed. China ranked first in the number of publications, while the United States had the highest citations and H-index. Jian Wang was the most prolific author. Zhejiang University was the institution with the highest number of publications. Frontiers in Microbiology was the journal with the most publications. Author keywords appearing more than 100 times included “intestinal microbiota/microbiome”, “microbiota/microbiome”, and “gut-lung axis”.Conclusion: The correlation and underlying mechanisms between intestinal microbiota and lung diseases, including asthma, COPD, lung cancer, and respiratory infections, remain hot topics in research. However, understanding the mechanisms involving the gut-lung axis is still in its infancy and requires further elucidation.

Background: Only implantable cardioverter defibrillators (ICD) have been proven to prevent sudden cardiac death (SCD) in patients with Brugada syndrome (BrS). However, ICD discharge, whether appropriate or inappropriate, leads to impaired quality of life and even increases rehospitalization. Quinidine might prevent the recurrence of ventricular arrhythmia (VA); however, the effect of low‐dose quinidine for preventing spontaneous arrhythmias remains less clear.Methods: In our cardiology center, 10 confirmed patients with BrS (all men, mean age 38.7 ± 6.72 years) who underwent appropriate ICD shocks due to recurrent VAs were treated with quinidine (≤200 mg/day) and followed regularly.Results: All the patients underwent ICD shocks due to ventricular tachycardia (VT)/ventricular fibrillation (VF) before taking quinidine. A 24‐hour distribution of VT/VF demonstrated that most of the events occurred in the sleeping time from 22:00 to 8:00. Quinidine prevented recurrence of VAs in nine patients. The other one patient took quinidine discontinuously because of anxiety suffered from less episodes of VA, and after psychological guidance, he took quinidine 200 mg/day and experienced no VA episodes from then on. In our series, only one patient suffered leukopenia related to quinidine. No other side effect was observed.Conclusions: Quinidine with a very low dose (≤200 mg/day) well controlled VT/VF recurrence for a long‐term period in Chinese patients with BrS. Administration (at 21:00) according to the circadian distribution of VT/VF episodes might increase the efficiency and improve the patient's tolerance.

Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe respiratory conditions with complex pathogenesis, in which endothelial cells (ECs) play a key role. Despite numerous studies on ALI/ARDS and ECs, a bibliometric analysis focusing on the field is lacking. This study aims to fill this gap by employing bibliometric techniques, offering an overarching perspective on the current research landscape, major contributors, and emerging trends within the field of ALI/ARDS and ECs.Methods: Leveraging the Web of Science Core Collection (WoSCC) database, we conducted a comprehensive search for literature relevant to ALI/ARDS and ECs. Utilizing Python, VOSviewer, and CiteSpace, we performed a bibliometric analysis on the corpus of publications within this field.Results: This study analyzed 972 articles from 978 research institutions across 40 countries or regions, with a total of 5,277 authors contributing. These papers have been published in 323 different journals, spanning 62 distinct research areas. The first articles in this field were published in 2011, and there has been a general upward trend in annual publications since. The United States, Germany, and China are the principal contributors, with Joe G. N. Garcia from the University of Arizona identified as the leading authority in this field. American Journal of Physiology-Lung Cellular and Molecular Physiology has the highest publication count, while Frontiers in Immunology has been increasingly focusing on this field in recent years. “Cell Biology” stands as the most prolific research area within the field. Finally, this study identifies endothelial glycocalyx, oxidative stress, pyroptosis, TLRs, NF-κB, and NLRP3 as key terms representing research hotspots and emerging frontiers in this field.Conclusion: This bibliometric analysis provides a comprehensive overview of the research landscape surrounding ALI/ARDS and ECs. It reveals an increasing academic focus on ALI/ARDS and ECs, particularly in the United States, Germany, and China. Our analysis also identifies several emerging trends and research hotspots, such as endothelial glycocalyx, oxidative stress, and pyroptosis, indicating directions for future research. The findings can guide scholars, clinicians, and policymakers in targeting research gaps and setting priorities to advance the field.

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Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that has turned out to be a pandemic all over the world. In China, some traditional Chinese herbal formulas have enjoyed a high reputation in T2DM treatment for centuries. Methods: In this study, ShenQi compound (SQC) is proposed, a formula that has been performed on T2DM clinical therapeutics in China for many years. The efficacy of SQC in a diabetic rat model by measuring food and water intake and examining islet microcirculatory index involves islets microvessel quantity and density, islets size, pancreatic microvascular wall thickness is evaluated. Meanwhile, gene microarray experiments were performed to explore the molecular mechanism of SQC treatment. In addition, a western medicine, metformin, was employed as a comparison. Results: The results indicated that SQC could effectively improve polydipsia, polyphagia and weight loss caused by diabetes as well as pancreatic tissue damage and vascular injury for T2DM. Meanwhile, the gene microarray experiments indicated that SQC may improve the T2DM by affecting the biological functions related to detection of chemical stimulus involved in sensory perception of smell, G-protein coupled receptor signaling pathway, cytoplasmic translation. In addition, SQC presented curative effect by the regulated function associated with translation, while metformin presented curative effect by the regulated function associated coagulation. Conclusion: SQC is an effective therapeutic drug on T2DM, and presents curative effect by regulated function associated with translation.

Background: Sepsis represents a critical medical condition that frequently progresses to acute respiratory distress syndrome (ARDS). While the traditional Chinese medicine Fusu agent (FSHJ) is clinically effective, its precise mechanisms in sepsis-induced ARDS remain unclear. Methods: To elucidate the therapeutic mechanisms of FSHJ in sepsis-induced ARDS, we implemented an integrated multi-method strategy combining network pharmacology, molecular dynamics simulations (MDS), liquid chromatography-mass spectrometry (LC-MS), and in vivo validation. Active compounds and targets of FSHJ were identified from Batman-TCM 2.0, followed by protein–protein interaction network construction via STRING. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were performed using clusterProfiler in R. Molecular docking with AutoDock Vina assessed binding affinities, and MDS with GROMACS verified complex stability. LC-MS confirmed the predicted bioactive components, while animal models experimentally validated the associated signaling pathways. Results: A total of 537 shared therapeutic targets were pinpointed among FSHJ, ARDS, and sepsis. Integrative assessments of protein–protein interaction (PPI) networks along with GO and KEGG enrichment analyses highlighted that the anti-sepsis-induced ARDS activity of FSHJ is predominantly mediated through inflammatory response regulation. Docking simulations combined with molecular dynamics analyses demonstrated that the key bioactive compound quercetin exhibited robust and sustained interactions with specific protein targets. LC-MS analyses further authenticated the presence of anticipated active compounds, particularly the glycoside derivative quercetin-3β-D-glucoside. Furthermore, all three doses of FSHJ effectively alleviated pathological lung tissue damage and systemic inflammatory responses induced by Escherichia coli (E. coli) infection. Relative to the control (model) group, FSHJ markedly suppressed the mRNA expression of inflammatory cytokines IL-6, IL-1β, and TNF-α, and decreased protein expression levels of TLR4 and NF-κB p65. Conclusion: Our findings indicate that FSHJ exerts protective effects in an E. coli-induced sepsis-associated ARDS mouse model, potentially through the regulation of TLR4/NF-κB-mediated inflammatory signaling pathways.