This study evaluates the feasibility and benefits of introducing battery-powered hybrid electric aircraft (HEA) into regional airline operations. Using 2019 U.S. domestic flight data, the ERJ175LR is selected as a representative aircraft, and several HEA variants are designed to match its mission profile under different battery technologies and power management strategies. These configurations are then tested across over 800 actual daily flight sequences flown by a regional airline. The results show that well-designed HEA can achieve 3–7% fuel savings compared to conventional aircraft, with several variants able to complete all scheduled missions without disrupting turnaround times. These findings suggest that HEA can be integrated into today’s airline operations, particularly for short-haul routes, without the need for major infrastructure or scheduling changes, and highlight opportunities for future co-optimization of aircraft design and operations.