The accelerated development of Artificial Intelligence (AI) capabilities and systems is driving a paradigm shift in productivity, innovation and growth. Despite this generational opportunity, AI is fraught with significant challenges and risks. To address these challenges, responsible AI has emerged as a modus operandi that ensures protections while not stifling innovations. Responsible AI minimizes risks to people, society, and the environment. However, responsible AI principles and practice are impacted by ‘principle proliferation’ as they are diverse and distributed across the applications, stakeholders, risks, and downstream impact of AI systems. This article presents a systematic review of responsible AI principles and practice with the objectives of discovering the current state, the foundations and the need for responsible AI, followed by the principles of responsible AI, and translation of these principles into the responsible practice of AI. Starting with 22,711 relevant peer-reviewed articles from comprehensive bibliographic databases, the review filters through to 9700 at de-duplication, 5205 at abstract screening, 1230 at semantic screening and 553 at final full-text screening. The analysis of this final corpus is presented as six findings that contribute towards the increased understanding and informed implementation of responsible AI.