Prof. Ching-Chi Chi

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Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

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1 December 2018 in JAMA Dermatology

Journal Article

Association of Psoriasis With Inflammatory Bowel Disease

Yun Fu

Cheng-Han Lee

Ching-Chi Chi

Psoriasis is a chronic systemic immune-mediated disorder affecting approximately 0.5% to 11.4% of adults and approximately 1.4% of children worldwide.¹^,2 Psoriasis has been characterized by sharply demarcated erythematous scaling plaques with a typical relapsing and remitting course.³^,4 Even with proper treatments, psoriasis can only be controlled but cannot be cured.⁵ Genetic and environmental factors are considered involved in the possible causes of psoriasis.⁶ Previous genome-based analysis revealed that specific genes (eg, PSORS1 [OMIM 177900], IL12B [OMIM 161561], and IL23R [OMIM 607562]) are predisposing factors for psoriasis.⁷ Psoriasis has been linked with a variety of comorbidities including cardiovascular diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic syndrome and its relevant components (obesity, hypertension, dyslipidemia, and type 1 and 2 diabetes), resulting in impaired quality of life and shortening of life expectancy.⁸^-18

1 September 2019 in JAMA Dermatology

Journal Article

Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease

Wei-Ti Chen

Ching-Chi Chi

Hidradenitis suppurativa (HS) or acne inversa is defined as “a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland–bearing areas of the body, most commonly the axillary, inguinal, and anogenital regions” (Dessau definition).¹^(p619) The etiology is largely unclear, but dysregulated inflammatory response of cytokines, follicular occlusion, obstruction and dilatation of the pilosebaceous unit, and altered microbiota may be involved in the pathogenesis of HS.²^-5

11 September 2020 in Nutrients

Journal Article

Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Non-Alcoholic Fatty Liver: A Systematic Review and Meta-Analysis

(1) Aim: Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease worldwide. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) bear anti-inflammatory action and can ameliorate hyperlipidemia. We wish to appraise the effects of n-3 PUFAs supplement on NAFLD. (2) Methods: We searched CENTRAL, Embase, and MEDLINE on 29 March 2020 for randomized control trials (RCTs) on the effects of n-3 PUFAs supplementation in treating NAFLD. The Cochrane Collaboration’s tool was used to assess the risk of bias of included RCTs. (3) Results: We included 22 RCTs with 1366 participants. The risk of bias of included RCTs was generally low or unclear. n-3 PUFAs supplementation significantly reduced liver fat compared with placebo (pooled risk ratio 1.52; 95% confidence interval (CI) 1.09 to 2.13). n-3 PUFAs supplementation also significantly improved the levels of triglyceride, total cholesterol, high-density lipoprotein, and body-mass index, with pooled mean difference and 95% CI being −28.57 (−40.81 to −16.33), −7.82 (−14.86 to −0.79), 3.55 (1.38 to 5.73), and −0.46 (−0.84 to −0.08), respectively. (4) Conclusions: The current evidence supports the effects of n-3 PUFAs supplementation in improving fatty liver. n-3 PUFAs supplementation may also improve blood lipid levels and obesity.

1 August 2021 in JAMA Dermatology

Journal Article

Chun-Hsien Huang

Yun Fu

Ching-Chi Chi

Quiz Ref ID As the most common type of hair loss, androgenetic alopecia (AGA) affects about 53% of European-American men aged 40 to 49 years in the United States and up to 90% in their lifetime.¹ Androgenetic alopecia is less prevalent in women and Asian individuals, affecting approximately 20% of men aged 40 to 49 years and 12% of women older than 70 years in China,² 14.1% of men and 5.6% of women at all ages in Korea,³ and 63% of men aged 17 to 86 years in Singapore.⁴ As an androgen-dependent trait, male-pattern hair loss is also strongly associated with multiple genetic factors.⁵ The cause of female-pattern hair loss is less well understood, but genetic predisposition is believed to play an important role. Androgenetic alopecia is characterized by the progressive recession of the frontal hairline followed by a vertex thinning and balding in men and diffuse hair thinning over the vertex scalp in women.⁶

1 November 2010 in Archives of Dermatology

Journal Article

The Association of Bullous Pemphigoid With Cerebrovascular Disease and Dementia

Kathy Taghipour

Ching-Chi Chi

Angela Vincent

Richard W. Groves

Vanessa Venning

Fenella Wojnarowska

Bullous pemphigoid (BP) is a debilitating autoimmune skin disease that is characterized by large, tense blisters on the skin of the elderly. It is associated with considerable morbidity and mortality and is the most common immunobullous disease in Europe, with an estimated incidence of 43 per million per year in the United Kingdom¹ and 7 to 13 per million per year in other parts of Europe.²^,3 The 2 major target antigens are BPAG1, a 230-kDa (BP230) cytoplasmic protein from the plakin family, and BPAG2, a 180-kDa transmembrane glycoprotein (BP180, collagen XVII). Both antigens are components of the hemidesmosomes of the basement membrane zone and play a role in cell-matrix adhesion. Tissue-bound and circulating antibodies of the IgG type recognize the autoantigens and deposit in a linear fashion along the basement membrane zone, leading to a characteristic immunofluorescence picture that is diagnostic of BP.

12 May 2009 in British Journal of Dermatology

Journal Article

Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes

Ching-Chi Chi

Tzu-Yu Wang

R. Charles-Holmes

C. Ambros-Rudolph

J. Powell

F. Wojnarowska

About Me

Professor Ching-Chi Chi is a Professor of Dermatology and General Convenor for Evidence-Based Medicine of Chang Gung Memorial Hospitals. He is also a Distinguished Professor at Chang Gung University. Prof. Chi is the Editor-in-Chief of Dermatologica Sinica, Deputy Co-ordinating Editor of Cochrane Skin, Associate Editor of the British Journal of Dermatology and JMIR Dermatology, and Immediate Past President and Honorary Director of the Taiwan Evidence-Based Medicine Association. He obtained his medical degree from Taipei Medical University and completed dermatology specialist training at Chang Gung Memorial Hospital, Taipei. Prof. Chi went on to obtain a Master of Medical Science from the Chung Shan Medical University. Prof. Chi obtained a D.Phil. in Clinical Medicine from the University of Oxford with a doctorate thesis entitled ‘Evidence-based assessment of the safety of topical corticosteroids in pregnancy’. He is passionate about evidence-based medicine and epidemiology and has authored over 190 articles, including 14 Cochrane reviews and 4 pan-European Dermatology Guidelines. Prof. Chi’s research interest includes psoriasis, clinical epidemiology, and medical education. Having published and been cited widely, Prof. Chi has received plenty of research awards, including the 2021 Outstanding Research Award from Taiwan’s National Science and Technology Council, and he was selected by the Stanford University and Elsevier BV as the 2019-2022 World’s Top 2% Scientist.

Prof. Ching-Chi Chi

Prof. Ching-Chi Chi

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