Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats. Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB methanol extract (150 and 300 mg/kg) was administered orally for 21 days. Results: α-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70 ± 0.13, 0.29 ± 0.03 μg/g, 139.32 ± 7.06 μg/100 g, 171.61 ± 6.05 mM ascorbic acid/g, 90.47 ± 4.11 mg GA/g and 37.39 ± 2.85 mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC₅₀ 67.34 ± 4.14 and 64.87 ± 4.68 μg/mL, respectively. Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.

Objective: In this study, women with habitual abortus (HA) and healthy control groups were determined for zinc (Zn), copper (Cu), manganese (Mn), selenium (Se), iron (Fe), cobalt (Co), chromium (Cr), nickel (Ni), lead (Pb), magnesium (Mg), calcium (Ca), sodium (Na), potassium (K), retinol, cholecalciferol, α-tocopherol, phylloquinone, total antioxidant (TAS) and total oxidation status (TOS) levels, also, and the relationships of these variables with HA were evaluated. Material and methods: The study included 39 women with HA and 39 healthy control subjects. In this study, trace element and mineral analyses by ICP-OES and vitamin analyses were determined using HPLC method. Results: Statistical analysis found that in the HA group was significantly lower than the control group with regarding cholecalciferol, phylloquinone, TAS, Se, Zn, Cu, Mg, K and Na levels (p < .05, p < .01, p < .01, p < .001, p < .05, p < .05, p < .01, p < .01 and p < .05). However, HA group was also significantly higher than control group regards to TOS, OSI and Ca⁄Mg levels (p < .05, p < .001, p < .05). In the HA group, significantly positive correlations were observed between phylloquinone and Ca (r = 0.495; p = .027), also, indicates negative significant correlation between cholecalciferol and Co (r = −0.598; p = .031). Conclusion: Our findings indicate that the results could be helpful in the monitoring of women with HA in terms of deficiency. It is important that in terms of the evaluation of phylloquinone, cholecalciferol Se, Zn, Cu, Mg and Ca/Mg ratio is required to consider.

The purpose of this study was to determine the antioxidant and antiradical activities in aqueous and ethanol extracts of Crataegus meyeri Pojark leaf, additionally, to examine some vitamins (A, E, C), trace elements (Cu, Zn, Mn, Se, Cr, Co). In this study, vitamin C, antioxidant and antiradical properties were determined using spectrophotometer. The results are compared with the reference antioxidants such as trolox, α-tocopherol and BHT. Levels of vitamin (A, E) measured using HPLC method. Trace elements were carried out using method of dry ashing with ICP-MS. The results of this study showed that C. meyeri leaf has a high antioxidant capacity and vitamin levels. C. meyeri is thought to be used as additives for food products and pharmaceutical industries with appropriate antioxidant properties and an antioxidant in future studies of experimental animal models, against free radicals generated in response to oxidative stress.

This study presents the phytochemical profile and in vitro and in vivo anticonvulsant and antioxidant activities of Epilobium hirsutum, which has been traditionally used in the treatment of epilepsy by local people of Turkey. In vitro studies revealed that the extract contained a pronounced amount of phenolics (206.3±0.9 mg Gallic acid Eq/g extract) and exhibited significant levels of antioxidant (FRAP; 6226 µmol Fe2+/g extract, ORAC; 6593 µmol Trolox Eq/g extract, DPPH; IC50:33.8 ug/mL and metal chelation; IC50:114 ug/mL) and anticonvulsant (AChE; IC50:71.2 ug/mL, BChE; IC50:92.5 ug/mL, GABA-T; IC50:94.7 ug/mL) activities. In vivo studies shown that the extract exhibited high anticonvulsant activities. In addition, the extracts regulated the behaviour, locomotion and mental activities of the mice tested. Biochemical evaluation of the brain tissue revealed that the extract inhibited the production of MDA and stimulated the increasing of antioxidant enzyme levels, which suggest the possible antioxidative role of the extract that worked as neuroprotective agents by scarfing the free radicals produced through PTZ seizure inducer and attenuate convulsions. Moreover the extract regulated serum biochemical parameters, total antioxidant, total oxidant, and ischemia-modified albumin levels. Chromatographic studies were revealed that gallic acid principally might be the major contributor of anticonvulsant and antioxidant activities with the additive contributions of fatty acids and mineral compounds. Findings obtained from this study partially justified the traditional use of Epilobium hirsutum in the treatment of epilepsy and suggest potential use of the extract as industrial or pharmaceutical agent.