Mirthala Flores-García

Dr. Mirthala Flores-García


Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
6 November 2025 in Biomedicines
Verified
Journal Article
Open access
PDF file
NPNonanzit Pérez-Hernández
Nonanzit Pérez-Hernández
JRJosé Manuel Rodríguez-Pérez
José Manuel Rodríguez-Pérez
LNLuis Eduardo Nicanor-Juarez
Luis Eduardo Nicanor-Juarez
ATAdriana Torres-Machorro
Adriana Torres-Machorro
RGRamon Garcia-Alva
Ramon Garcia-Alva
MFMirthala Flores-García
Mirthala Flores-García
Peripheral arterial disease (PAD) is a complex, multifactorial atherosclerotic disease that primarily affects the arteries supplying the lower extremities, causing significant occlusion and reduced blood flow. Several studies have found an association between PAD and both genetic and environmental factors, which play a key role in the disease’s pathophysiology. Therefore, in this review, we describe the main genetic variants associated with plaque initiation, progression, and rupture in PAD. Furthermore, we identify different KEGG pathways involved in the pathological processes of these genes. We also describe gene expressions or transcriptomic studies, particularly in biopsies from patients with PAD. These findings could help identify the functional impact of genetic variants on the disease phenotype and, consequently, allow for the development of appropriate interventions that improve patient prognoses.

31 March 2026 in Biophysica
Verified
Journal Article
Open access
PDF file
ICIXCHEL IXCHEL RAMIREZ CAMACHO
IXCHEL IXCHEL RAMIREZ CAMACHO
FCFernando León Cedeño
Fernando León Cedeño
JCJosé Germán Vázquez Cuevas
José Germán Vázquez Cuevas
EGEVA FLORENCIA LEJARAZO GOMEZ
EVA FLORENCIA LEJARAZO GOMEZ
UMUlises Martínez-Ortega
Ulises Martínez-Ortega
FOFausto Alejandro Jimenez Orozco
Fausto Alejandro Jimenez Orozco
Novel pharmacological approaches advocate developing multitarget drugs, that is, molecules capable of simultaneously acting on two or more pharmacological targets to produce synergistic effects from a single compound in each disease. This strategy may help reduce required doses and prevent drug–drug interactions typically associated with polypharmacy. Coumarins are natural products with diverse pharmacological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective, cardioprotective, and antithrombotic effects. The pleiotropic actions of these molecules suggest that modifying the coumarin structure could yield new multi-target antiplatelet agents with greater efficacy and safety than those currently available in clinical practice. In this work, we began with a theoretical approach using molecular docking and designed three coumarins that simultaneously inhibited platelet aggregation induced by epinephrine, collagen, and ADP. Experimentally, we evaluated the structure activity relationship of three coumarins: (A) 6,7-dimethoxy-3-(1H-pyrrol-1-yl)-2H-chromen-2-one, (B) 7,8-dimethoxy-3-(1H-pyrrol-1-yl)-2H-chromen-2-one, and (C) 3-(1H-imidazol-1-yl)-6,7-dimethoxy-2H-chromen-2-one. In silico studies suggest that compounds B and C may exhibit antagonistic interactions at the α2-adrenergic, GPVI collagen, and P2Y12 ADP receptors. Additionally, molecular docking indicates essential interactions between the compounds and the GPIIb/IIIa fibrinogen receptor.