Hepatocellular carcinoma (HCC) is a malignancy with a complex pathogenesis, course, and prognosis with increasing incidence. The most significant contributing factor to the development of HCC is the chronic process of inflammation and remodeling of the cirrhotic liver, in which the interaction between the tumor microenvironment (TME) and cancer cells plays a pivotal role. In recent years, increasing focus has been directed toward the role of platelets (PLTs) in mediating interactions between tumor cells and the TME and in the progression and spread of HCC, as well as other cancers. Due to their abundance in the bloodstream and intracellular granules rich in mediators facilitating their ability to modulate the immune system, PLTs play a significant role in carcinogenesis. In the context of HCC, the role of PLTs in the healing and regeneration processes of the liver has been recognized for some time. In recent years, there has been an increasing utilization of PLTs in prognostic models for patients with HCC. Given their role and the availability of clinical options that block PLTs’ action, clinical trials of platelet blockers in the adjunctive treatment of HCC are becoming increasingly common. However, further research, both preclinical and clinical, is necessary to fully elucidate the role of PLTs in HCC and their potential use as a therapeutic target. In this literature review, we summarize the current knowledge on PLTs in HCC and focus on their potential use in everyday clinical practice.

Loeys-Dietz Syndrome is an autosomal dominant disorder concerning the connective tissue. SCAD is the underlying cause of 1.7% to 4% of ACS and accounts for 0.5% of sudden cardiac deaths. Furthermore, in young women <60 years of age, SCAD accounts for 22% to 35% of ACS presentations. A...

A 37-year-old male with Ebstein’s anomaly was admitted due to clinical signs of right ventricle dysfunction. The patient had five prior sternotomies due to bioprostheses insertion at the site of the tricuspid position. Echo showed normal left ventricular function and significantly dilated right...