Dominant (right) and nondominant (left) hand differences in motor performance variables were investigated during targeted rapid aiming unimanual and bimanual (to two separate targets) speed-accuracy tasks. The performance of the dominant and nondominant hands were compared during rapid targeted unimanual and bimanual reaching tasks (50 repetitions) in adult, neurologically intact, right-handed men ( n = 20). As task difficulty increased from unimanual to bimanual tasks, reaction time increased and velocity (average and maximal) of performance decreased significantly. The effect of hand was significant only on average movement velocity and on intraindividual variability of accuracy (in both cases performance in the left hand was worse). Variability of movement path (accuracy) was less in the right hand during both unimanual and bimanual tasks.

Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effects in pathological conditions with chronically increased ROS. Here, young male volunteers were exposed to 3 weeks of unloading of the dominant leg followed by 3 weeks of resistance training without (Ctrl group) or with the addition of all-out cycling HIIT. Changes in muscle thickness were assessed by ultrasonography, and contractile function was studied by measuring the torque during maximal voluntary contractions (MVC). The results show an ~6% decrease in vastus lateralis thickness after the unloading period, which was fully restored after the subsequent training period in both the Ctrl and HIIT groups. MVC torque was decreased by ~11% after the unloading period and recovered fully during the subsequent training period in both groups. All-out cycling performance was improved by the 3 weeks of HIIT. In conclusion, the decline in muscle size and function after 3 weeks of unloading was restored by 3 weeks of resistance training regardless of whether it was combined with HIIT.

Background/Objectives: Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remain unknown. This study aimed to evaluate whether short-term supplementation with broccoli-derived glucoraphanin improves recovery from exercise-induced muscle damage. We hypothesized that short-term supplementation with broccoli-derived glucoraphanin would attenuate exercise-induced muscle damage and accelerate recovery. Methods: In a randomized, double-blind, placebo-controlled crossover design, fifteen participants consumed either high-glucoraphanin broccoli powder (320 μg) or placebo for two weeks, followed by elbow flexor eccentric exercise. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology were measured at baseline, immediately post-exercise, and at 48 and 96 h post-exercise. Results: Significant main effects of time were observed for isometric and isokinetic torque (p < 0.05), CK (p < 0.05), soreness (p < 0.05), and structural swelling markers (p < 0.05), confirming exercise-induced muscle damage. However, there were no significant Time × Supplement interactions for any variable (p > 0.05), indicating that glucoraphanin did not influence recovery dynamics. Conclusions: These findings suggest that short-term high-dose broccoli supplementation reconstituted with hot water does not modulate recovery following eccentric muscle damage under the conditions tested, including the chosen preparation method and experimental context.

Objectives: Neuromyelitis optica (NMO) is frequently associated with aquaporin‐4 autoantibodies (AQP4‐Ab); however, studies of NMO in Lithuania are lacking. Therefore, the main objective of our study is to assess positivity for AQP4‐Ab in patients presenting with inflammatory demyelinating central nervous system (CNS) diseases other than typical multiple sclerosis (MS) in Lithuania. Materials and methods: Data were collected from the two largest University hospitals in Lithuania. During the study period, there were 121 newly diagnosed typical MS cases, which were included in the MS registry database. After excluding these typical MS cases, we analyzed the remaining 29 cases of other CNS inflammatory demyelinating diseases, including atypical MS ( n = 14), acute transverse myelitis, TM ( n = 8), acute disseminated encephalomyelitis, ADEM ( n = 3), clinically isolated syndrome, CIS ( n = 2), atypical optic neuritis, ON ( n = 1), and NMO ( n = 1). We assessed positivity for AQP4‐Ab for the 29 patients and evaluated clinical, laboratory, and instrumental differences between AQP4‐Ab seropositive and AQP4‐Ab seronegative patient groups. Results: AQP4‐Ab test was positive for three (10.3%) patients in our study, with initial diagnoses of atypical MS ( n = 2) and ADEM ( n = 1). One study patient was AQP4‐Ab negative despite being previously clinically diagnosed with NMO. There were no significant clinical, laboratory, or instrumental differences between the groups of AQP4‐Ab positive (3 [10.3%]) and negative (26 [89.7%]) patients. Conclusions: AQP4‐Ab test was positive for one‐tenth of patients with CNS inflammatory demyelinating diseases other than typical MS in our study. AQP4‐Ab testing is highly recommended for patients presenting with not only TM and ON but also an atypical course of MS and ADEM.

Background/Objectives: This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli powder-derived sulforaphane bioavailability and its effects in attenuating exercise-induced oxidative stress. Methods: Seventeen healthy males (age 23.8 ± 4.9 years, height 182.3 ± 6.1 cm, weight 80.0 ± 12.8 kg), in a double-blind crossover design, three weeks apart, consumed ten standard doses of either broccoli powder or spinach powder as a placebo over a period of 2 weeks. They then performed a maximal progressive cycling task with concomitant analysis of expired gas composition. Plasma malondialdehyde (MDA) level was measured before and 60 min after the completion of the task, and blood lactate and muscle power (counter-movement vertical jump (CMJ) performance) were measured before and up to 60 min after exercise. Results: The main findings were that despite urine sulforaphane output being markedly higher following broccoli supplementation (p < 0.05), which confirms effective absorption and systemic availability of the compound, this did not influence exercise-induced changes in plasma MDA concentration, blood lactate dynamics, exercise test performance, or functional recovery measured as muscle power via CMJ performance (p > 0.05). Conclusions: In conclusion, broccoli powder supplementation, despite efficient delivery of sulforaphane, does not seem to either acutely affect performance or modify oxidative stress and recovery from metabolically demanding exercise.

Background. Research aim was to evaluate the effect of the application of constraint-induced movement therapy on the recovery of affected hand function after stroke. Research hypothesis: The application of constraint-induced movement therapy on the recovery of affected hand function after stroke would be more effective than the application of conventional physiotherapy. Methods. The study employed the Mini Mental State Examination (MMSE), Lovett’s test, Modified Movement Assessment Scale (MMAS) hydraulic dynamometer, and Wolf Motor Function Test. Results. Results showed that constraint – induced movement therapy for patients after stroke helps to recover injured hand movement more effectively (p < .05), enhances performance of functional tasks (p < .05) and also increases muscle strength (p < .05) compared to conventional physiotherapy.Conclusions. After the application of the conventional physiotherapy for patients after stroke affected hand movements and functional task performance improved and the hand grip strength increased statistically significantly. Applying the constraint-induced movement therapy for patients after stroke affected hand movements and functional task performance improved and the hand grip strength increased statistically significantly. The application of constraint-induced movement therapy for patients after stroke statistically significantly more improved the affected hand function than the application of conventional physiotherapy.Keywords: constraint-induced movement therapy, stroke, hand function, rehabilitation, physiotherapy.