In this paper, a flexible CPW fed ultrawide band (UWB) antenna with mu-negative (MNG) metamaterial is designed, fabricated, and tested for wearable applications. Initially, a UWB antenna of size 50 mm × 43 mm is fabricated on two different substrates, viz. flexible FR4 and semi-flexible Rogers RT/duroid 5880. A metamaterial structure fabricated on flexible FR4 shows a magnetic resonance from 7.2 GHz to 9.2 GHz with maximum stop band attenuation (−49 dB) and high MNG value (−2121.6) at 7.87 GHz. Then a (3 × 3) array of designed MNG metasurface is used as ground plane with flexible UWB antenna, which improves its overall gain and radiation pattern. The performance of the flexible antenna with/without metamaterial at various distances from flat and cylindrical three-layered human phantom of skin, fat, and muscle is studied. Further, the bending characteristics at different angles and performance over thin metallic sheet is also evaluated. Additionally, the peak specific absorption rate value averaged over 1 g of tissue at three chosen frequencies from UWB range (3, 5, 10 GHz) with/without metamaterial using 0.3 and 0.1 W of input power is also analyzed. The simulated and measured results are in good agreement which confirms that the designed antenna is a good candidate for wearable applications.