This numerical study introduces a surface plasmon resonance (SPR)-based biosensor utilizing a kagome lattice-inspired hollow core photonic crystal fiber (PCF) for the highly sensitive detection of various blood biomarkers and analytical components. The sensor is designed to detect key blood biomarkers such as water, glucose, plasma, and hemoglobin (Hb), as well as analytical targets including krypton, sylgard, ethanol, polyacrylamide (PA), and bovine serum albumin (BSA), by monitoring shifts in the resonance wavelength (RW). A dual-polarization approach is employed by analyzing both transverse magnetic (TM) and transverse electric (TE) modes. The proposed sensor demonstrates exceptional performance, achieving maximum wavelength sensitivities (Sw) of 18,900 nm RIU⁻¹ for TM pol. and 16,800 nm RIU⁻¹ for TE pol. Corresponding peak amplitude sensitivities (S_A) of 71,224 RIU⁻¹ for TM pol. and 58,112 RIU⁻¹ for TE pol. were also observed. The peak sensor resolution (S_R) for both modes is on the order of 10⁻⁶ RIU, underscoring its high precision. Owing to its enhanced sensitivity, compact design, and robust dual-polarization capability, the proposed biosensor holds strong promise for point-of-care diagnostics and real-time blood component analysis.

Optical tweezers can rapidly manipulate dielectric objects for applications ranging from microcentrifuges to controlling droplets and particles in a “lab-in-air” configuration. Here, we uniquely combine light propagation that is predominantly parallel to the particle’s orbital track—rather than primarily perpendicular as in conventional vortices—with operation in air. We measure a 7-micrometer sphere circulating at 20,400 rounds per minute [340 hertz (Hz)] along 120-micrometer circumference tracks, achieving accelerations up to 10 times that of gravity (98 square meters per second). Our trap’s optical orbital angular momentum of ℓ = 242ℏ per photon, combined with the gaseous environment, enables high circulation frequencies and underdamped operation at a high mechanical quality factor, Q . Together, our Q - f product of 5300 Hz facilitates low dissipation in combination with rapid particle manipulation. This advancement could substantially expand the impact of dynamic optical traps, particularly in fundamental measurements.