Valdano Manuel

Prof. Dr. Valdano Manuel

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Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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29 November 2019 in Journal of Cardiac Surgery
Verified
Journal Article
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VMValdano Manuel
Valdano Manuel
LMLeonardo A. Miana
Leonardo A. Miana
GGGustavo P. Guerreiro
Gustavo P. Guerreiro
DTDavi F. Tenório
Davi F. Tenório
ATAida Turquetto
Aida Turquetto
MJMarcelo B. Jatene
Marcelo B. Jatene

4 May 2021 in World Journal for Pediatric and Congenital Heart Surgery
Verified
Journal Article
Closed access
PDF file
CTChristo I. Tchervenkov
Christo I. Tchervenkov
CHClaudia Herbst
Claudia Herbst
JJJeffrey Phillip Jacobs
Jeffrey Phillip Jacobs
ZAZohair Al-Halees
Zohair Al-Halees
FEFrank Edwin
Frank Edwin
RJRichard A. Jonas
Richard A. Jonas
The optimal training of the highly specialized congenital heart surgeon is a long and complex process, which is a significant challenge in most parts of the world. The World Society for Pediatric and Congenital Heart Surgery (WSPCHS) has established the Global Council on Education for Congenital Heart Surgery as a nonprofit organization with the goal of assessing current training and certification and ultimately establishing standardized criteria for the training, evaluation, and certification of congenital heart surgeons around the world. The Global Council and the WSPCHS have reviewed the present status of training and certification for congenital cardiac surgery around the world. There is currently lack of consensus and standardized criteria for training in congenital heart surgery, with significant disparity between continents and countries. This represents significant obstacles to international job mobility of competent congenital heart surgeons and to the efforts to improve the quality of care for patients with Congenital Heart Disease worldwide. The purpose of this article is to summarize and document the present state of training and certification in congenital heart surgery around the world.

21 May 2021 in Cardiology in the Young
Verified
Journal Article
Closed access
PDF file
VMValdano Manuel
Valdano Manuel
LMLeonardo A. Miana
Leonardo A. Miana
ATAida Turquetto
Aida Turquetto
GGGustavo Pampolha Guerreiro
Gustavo Pampolha Guerreiro
NFNatália Fernandes
Natália Fernandes
MJMarcelo Biscegli Jatene
Marcelo Biscegli Jatene
Introduction: Acute kidney injury is a risk factor for chronic kidney disease and mortality after congenital heart surgery under cardiopulmonary bypass. The neutrophil–lymphocyte ratio is an inexpensive and easy to measure biomarker for predicting outcomes in children with congenital heart disease undergoing surgical correction.Objective: To identify children at high risk of acute kidney injury after tetralogy of Fallot repair using the neutrophil–lymphocyte ratio.Methods: This single-centre retrospective analysis included consecutive patients aged < 18 years who underwent tetralogy of Fallot repair between January 2014 and December 2018. The pre-operative neutrophil–lymphocyte ratio was measured using the last pre-operative complete blood count test. We used the Acute Kidney Injury Network definition.Results: A total of 116 patients were included, of whom 39 (33.6%) presented with acute kidney injury: 20 (51.3%) had grade I acute kidney injury, nine had grade II acute kidney injury (23.1%), and 10 (25.6%) had grade III acute kidney injury. A high pre-operative neutrophil–lymphocyte ratio was associated with grade III acute kidney injury in the post-operative period (p = 0.04). Patients with acute kidney injury had longer mechanical ventilation time (p = 0.023), intensive care unit stay (p < 0.001), and hospital length of stay (p = 0.002).Conclusion: Our results suggest that the pre-operative neutrophil–lymphocyte ratio can be used to identify patients at risk of developing grade III acute kidney injury after tetralogy of Fallot repair.

10 February 2021 in Journal of Cardiac Surgery
Verified
Journal Article
Closed access
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VMValdano Manuel
Valdano Manuel
LMLeonardo Augusto Miana
Leonardo Augusto Miana
DSDavi J. Fontoura Solla
Davi J. Fontoura Solla
NFNatália Fernandes
Natália Fernandes
GCGabriel Carrillo
Gabriel Carrillo
MJMarcelo Biscegli Jatene
Marcelo Biscegli Jatene

1 January 2021 in Brazilian Journal of Cardiovascular Surgery
Verified
Journal Article
Open access
VMValdano Manuel
Valdano Manuel
LMLeonardo A. Miana
Leonardo A. Miana
GGGustavo Pampolha Guerreiro
Gustavo Pampolha Guerreiro
ATAida Turquetto
Aida Turquetto
RSRômullo Medeiros Santos
Rômullo Medeiros Santos
MJMarcelo Biscegli Jatene
Marcelo Biscegli Jatene
Elevated neutrophil-lymphocyte ratio (NLR) has been associated with poorer outcomes in cyanotic patients undergoing single ventricle palliation. Little is known about this biomarker on patients with tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. Our objective is to study the impact of preoperative NLR on outcomes of TOF patients undergoing total repair. This retrospective study included 116 consecutive patients between January 2014 and December 2018. Preoperative NLR was measured from the last complete blood count test before the surgery. Using the cutoff value of 0.80, according to the receiveroperating characteristic (ROC) curve, the sample was divided into two groups (NLR < 0.80 and ≥ 0.80). The primary endpoint was hospital length of stay (LOS). ROC curves showed that higher preoperative NLR was associated with longer hospital LOS, with an area under the curve of 0.801±0.040 (95% confidence interval 0.722 - 0.879; P<0.001). High preoperative NLR was also associated with long intensive care unit (ICU) LOS (P=0.035). Preoperative NLR predicted longer hospital LOS with a sensitivity of 63% and a specificity of 81.4%. Higher preoperative NLR was associated with long ICU and hospital LOS in patients undergoing TOF repair.

6 March 2019 in World Journal for Pediatric and Congenital Heart Surgery
Verified
Journal Article
Open access
PDF file
VMValdano Manuel
Valdano Manuel
HMHumberto Morais
Humberto Morais
ATAida L. R. Turquetto
Aida L. R. Turquetto
GMGade Miguel
Gade Miguel
LMLeonardo A. Miana
Leonardo A. Miana
AJAntónio P. F. Júnior
António P. F. Júnior
Single ventricle physiology management is challenging, especially in low-income countries. To report the palliation outcomes of single ventricle patients in a developing African country. We retrospectively studied 83 consecutive patients subjected to single ventricle palliation in a single center between March 2011 and December 2017. Preoperative data, surgical factors, postoperative results, and survival outcomes were analyzed. The patients were divided by palliation stage: I (pulmonary artery banding [PAB] or Blalock–Taussig shunt [BTS]), II (Glenn procedure), or III (Fontan procedure). Of the 83 patients who underwent palliation (stages I-III), 38 deaths were observed (31 after stage I, six after stage II, and one after stage III) for an overall mortality of 45.7%. The main causes of operative mortality were multiple organ dysfunction due to sepsis, shunt occlusion, and cardiogenic shock. Twenty-eight survivors were lost to follow-up (22 after stage I, six after stage II). Thirteen stage II survivors are still waiting for stage III. The mean follow-up was 366 ± 369 days. Five-year survival was 28.4 % for PAB and 30.1% for BTS, while that for stage II and III was 49.8% and 57.1%, respectively. Age (hazard ratio, 0.61; 95% confidence interval: 0.47-0.7; P = .000) and weight at surgery (hazard ratio, 0.45; 95% confidence interval: 0.31-0.64; P = .002) impacted survival. A high-mortality rate was observed in this initial experience, mainly in stage I patients. A large number of patients were lost to follow-up. A task force to improve outcomes is urgently required.