Fabrizio Sanna

Dr. Fabrizio Sanna

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 August 2025 in Bioengineering
Verified
Journal Article
Open access
PDF file
SASamuele Avolese
Samuele Avolese
SPSimone Parrini
Simone Parrini
ALAndrea Tancredi Lugas
Andrea Tancredi Lugas
CBCristina Bignardi
Cristina Bignardi
MTMara Terzini
Mara Terzini
FSFabrizio Sanna
Fabrizio Sanna
Background: The fabrication of orthodontic aligners directly via three-dimensional (3D) printing presents potential to increase the efficiency of aligner production relative to traditional workflows; however, several aspects of the 3D printing process might affect the dimensional fidelity of the fabricated appliances. The aim of this study is to measure the forces expressed by a 3D printed aligner made with TC-85 DAC resin (Grapy Inc., Seoul, Republic of Korea) when an expansion movement of the entire upper dental arch is programmed, comparing the measured forces with those obtained by a common thermoformed aligner (Smart Track®, Align Technology, Santa Clara, CA, USA). Materials and methods: A patient in transitional mixed dentition was selected, with the presence of all the first molars and permanent upper and lower incisors, and the canines and premolars have not started the exchange. From this patient, a virtual set up of the upper arch has been planned with an expansion of 0.2 mm and 0.4 mm per side; 3 mm horizontal rectangular attachments were added to the set up on the vestibular surface of the permanent molars, deciduous premolars, and deciduous canines. On this set up, 10 Smart Track aligners and 10 3D printed aligners with TC-85 DAC resin were produced. The fabricated aligners were mounted on the machinery used for the test (ElectroForce® Test Bench; TA Instruments, New Castle, DE, USA) by means of specific supports that simulate the upper arch of the patient (divided into two sides: right and left). To simulate the intraoral environment, the measurements were carried out in a thermostatic bath at a temperature of 37 °C. Results: The key results of this paper showed differences between Smart Track® and TC-85 DAC. In particular, the expanding force exerted by the 0.2 mm per side expanded Smart Track® aligners was on average +0.2162 N with a D.S. of ±0.0051 N during the 8 h; meanwhile, the force exerted by the 0.2 mm per side expanded TC-85 DAC 3D printed aligners was on average −0.0034 N with a D.S. of ±0.0036 N during the 8 h. The force exerted by the 0.4 mm per side expanded Smart Track® aligners was on average +0.7159 N with a D.S. of ±0.0543 N during the 8 h; meanwhile, the force exerted by the 0.4 mm per side expanded TC-85 DAC 3D printed aligners was on average +0.0141 N with a D.S. of ±0.004 N during the 8 h. Conclusions: Smart Track® aligners express a quantitatively measurable force in Newtons during the programmed movements to obtain a posterior expansion of the dental arches; on the contrary, aligners made with TC-85 DAC resin, in light of the results obtained from this study, express forces close to 0 during the realization of the movements programmed to obtain a posterior expansion of the dental arches.

2 April 2026 in PLOS ONE
Verified
Journal Article
Open access
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FSFabrizio Sanna
Fabrizio Sanna
Leila Es SebarLeila Es Sebar
Leila Es Sebar
ISIsabella Sannino
Isabella Sannino
SASamuele Avolese
Samuele Avolese
SPSimone Parrini
Simone Parrini
Alovisi MarioAlovisi Mario
Alovisi Mario
Introduction: Align Technology, Inc. is a leading manufacturer of orthodontic aligners, using SmartTrack TM (LD30), a multilayer aromatic thermoplastic polyurethane/copolyester, and the vacuum thermoforming process. Recently, direct 3D printing using Tera Harz TC-85 DAC resin has also been explored for the production of aligners. Both aligner materials are exposed to physical and chemical aging in the oral cavity. This study evaluates the chemical aging of these materials after 7 and 14 days of exposure to the oral environment, using Optical Microscopy, Raman spectroscopy, X-ray fluorescence (XRF), and X-ray diffraction (XRD). Materials and methods: Invisalign® aligners (SmartTrack TM LD30) and 3D printed aligners (Tera Harz TC-85 DAC) were worn by 20 patients for 7 ( t 1 ) and 14 days ( t 2 ). The aligners were characterized initially ( t 0 ) using Optical Microscopy, Raman spectroscopy, XRF, and XRD. After t 1 and t 2 , each aligner was reanalyzed at three locations: right and left first molars ( p 1 and p 2 ), and central incisor ( p 3 ). The results were compared with never-worn aligners ( t 0 , n = 3). Results: Both materials showed high homogeneity across all locations ( p 1 , p 2 , p 3 ) and time points, indicating uniform performance after oral exposure. PCA analysis performed on Raman spectra revealed no significant chemical changes in the surface composition after 7–14 days of use. Discussion and conclusions: The results demonstrated that exposure to the oral environment for up to 14 days did not significantly alter the surface chemistry of either aligner material. These findings are consistent with recent literature, suggesting that short-term intra-oral exposure does not affect aligner materials’ chemical stability.

3 August 2025 in Bioengineering
Verified
Journal Article
Open access
PDF file
Tommaso CastroflorioTommaso Castroflorio
Tommaso Castroflorio
SASamuele Avolese
Samuele Avolese
FSFabrizio Sanna
Fabrizio Sanna
SPSimone Parrini
Simone Parrini
Objective: To evaluate the concordance of automated 3D superimposition methods applied to digital models, with a focus on methods that consider stable palatal regions as geometric reference landmarks versus those that do not. Design and setting: This was a prospective, cross-sectional study using digital model files of patients undergoing orthodontic treatment in a university clinical setting. Participants: Sixty-one patients were prospectively enrolled and divided into three groups based on the type of orthodontic treatment they received: (20) non-extractive orthodontic treatment without intermaxillary elastics, (21) intermaxillary elastics, and (20) control subjects with no orthodontic movement. The inclusion criteria included the availability of complete pre- and post-treatment digital casts and the absence of significant craniofacial anomalies. Methods: Three superimposition methods were tested: (1) superimposition according to palate and palatal ridges, (2) best-fit superimposition of arches in occlusion, and (3) best-fit superimposition of individual arches. Discrepancies were identified by comparing the spatial positions derived from each method. Within three spatial axes, deviations of ±0.5 mm and ±1.15° were not considered significant. Bland–Altman plots were used to quantify palatal rugae based and non-based spatial differences between methods. Differences in the superimposition results between the three patient groups were evaluated using ANOVA tests. Results: Differences in spatial position between the superimposition methods often exceeded the acceptable range. The results were compared between the three patient groups with a statistical significance of α = 0.05. In the present study, the high reliability of the superimposition method based on the palate and palatal ridges was observed. Conclusion: Superimposition methods based on the palate and palatal rugae provide superior accuracy in determining treatment-related changes in upper arch digital models. These findings illustrate the need for appropriate selection of superimposition techniques based on the study objective of using clinically relevant techniques.

Verified
Journal Article
Open access
PDF file
SASamuele Avolese
Samuele Avolese
FSFabrizio Sanna
Fabrizio Sanna
SPSimone Parrini
Simone Parrini
GCGiada Chiarello
Giada Chiarello
DLDanila Lava
Danila Lava
Nicola ScottiNicola Scotti
Nicola Scotti
Background: This study aimed to investigate the dimensional deformation that can occur during the fabrication of a 3D-printed aligner made with the TC-85 DAC resin (Graphy Inc., Seoul, Republic of Korea) and determine if the manual removal of the print supports before final aligner curing affects the dimensional accuracy. Methods: 10 subjects with permanent dentition were selected, and a set of aligners was digitally designed using the uDesign Direct Aligner beta software (Graphy Inc., Seoul, Republic of Korea). Each aligner was 3D-printed using TC-85 DAC resin (Graphy Inc., Seoul, Republic of Korea) twice: one copy was produced removing the print supports before final curing, whereas the other was cured with the supports still attached. The aligners were digitized and compared to the original design of the digitally designed aligner using RMS and Inter-second molar distance data to identify variations between 3D-produced aligners and their respective digital design. Results: the comparison between aligners produced in two different ways was statistically significant with a p-value < 0.0001 for both the records used. Conclusions: the manual removal of the print supports before final curing affects the dimensional accuracy of aligners made by direct 3D printing, permanently altering the aligner’s internal geometry, confirming that post-processing conditions significantly affect dimensional stability.