Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High‐throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thiopyridinone backbone and select 2‐mercaptonicotinoyl glycine (2‐MNG) as exhibiting the most favorable balance between the impact on water footprint, skin penetration potential and performance. The effectiveness of 2‐MNG was confirmed by topical application on pigmented reconstructed epidermis and human skin explants. In addition, experiments have shown that unlike most melanogenesis inhibitors on the market, this molecule is not a tyrosinase inhibitor. 2‐MNG binds to certain melanin precursors, preventing their integration into growing melanin and leading to inhibition of eumelanin and pheomelanin synthesis, without compromising the integrity of melanocytes.

Patients with posttraumatic stress disorder (PTSD) might have white matter abnormalities. However, less is known about white matter changes after exposing a specific traumatic event. The purpose of this study was to explore the abnormalities of diffusion in cerebral white matter and its relationship with the clinical symptoms in patients with PTSD by using diffusion tensor imaging (DTI). Diffusion-weighted imaging of the cerebrum was performed in typhoon survivors with (n = 27) and without PTSD (n = 33) and healthy controls (HCs) (n = 30). Differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated among groups using voxel-based analysis of the DTI data. Correlations between diffusion indices and clinical symptoms in patients with PTSD were also assessed. Both patients with PTSD and trauma-exposed control (TEC) group showed increased FA in the anterior limb of the internal capsule, forceps of the corpus callosum, and corona radiata relative to the HC group. Additionally, there was a negative correlation between FA values in the white matter and the clinical symptoms. Trauma exposure may result in disruption of cerebral white matter in individuals with or without PTSD, particularly in the frontal fibers. Aberrant white matter alterations may be associated with the severity of PTSD symptoms.

Objective: To investigate the repairing and anti‐wrinkle efficacy of the facial cream enriched with C‐xyloside, aiming at comprehensively evaluating its skin anti‐ aging effect and clarify its potential mechanism of action.Methods: The repairing efficacy was studied on 3D epidermis skin model and the antiaging efficacy was studied on ex‐vivo human skin. Two clinical studies were conducted with Chinese females. In the first study, 49 subjects aged between 30 and 50 with wrinkle concerns were recruited and instructed to apply the investigational cream containing C‐xyloside for 8 weeks. Wrinkles attributes were assessed by dermatologist. Instrumental measurements on skin hydration, trans‐epidermal water loss (TEWL), and skin elasticity were also conducted. In the second study, 30 subjects aged between 25 and 60 with self‐declared sensitive skin and facial redness were recruited and instructed to apply the cream for 4 weeks. Biomarker analysis of the stratum corneum was conducted through facial tape strips.Results: The cream improved the histomorphology of the 3D epidermis skin model after SLS stimulation, and significantly increase the expression of LOR and FLG. On human skin, the cream improved the histopathology induced by UV, and significantly increased the protein content of COL I and COL III, collagen density and the number of Ki‐67 positive cell of skin compared with model group (n = 3, p < 0.01). The results from the first clinical study demonstrate a significant increased the skin hydration and elasticity by 21.90%, 13.08% (R2) and 12.30% (R5), respectively (n = 49, p < 0.05), and the TEWL values decreased by 33.94% (n = 49, p < 0.05), after 8 weeks application of the cream. In addition, the scores for nasolabial folds, glabellar wrinkle, underneath eye wrinkles, crow's feet wrinkle and forehead wrinkle in the volunteers exhibited a significant reduction of 34.02%, 43.34%, 50.03%, 33.64% and 55.81% respectively (n = 49, p < 0.05). The (rCE)/(fCE) ratio of volunteers based on tape stripping significant increased after using the sample cream (n = 30, p < 0.05).Conclusion: The cream containing C‐xyloside showed improvement of skin wrinkles and enhancement of skin barrier function. These efficacies may be attributed to the fact that the sample cream can increase the expression of skin barrier related proteins LOR and FLG, promote the maturation of cornified envelope, enhance collagen I and III protein expression and stimulate skin cell proliferation, to provide sufficient evidence supporting its antiaging efficacy of skin.

In order to solve the issue of identifying depression tendency hidden in microblog text, a depression emotional inclination recognition model based on emotional decay factor is proposed. Make the self-rating depression scale, collect students’ microblog text and ask the psychology specialist to annotate the microblog artificially. Construct the depressive emotion dictionary, and then build a depression emotion classifier based on support vector machine. Considering the continuity of depression mood swing, the mathematical model of emotional decay factor is constructed to realize the continuity of discrete emotional state. The experimental results show that the model can effectively identify the depression of user for a period of time, the recognition accuracy rate is 83.82%.

Background and Aim: Skin tone contributes critically to facial attractiveness; skin aging yellowness has become a predominant aging and skin tone concern in the Asian population. However, the clinical parameters underlying the visual perception of skin yellowness remain elusive. This study explored the relevant clinical parameters and exposome factors influencing the perception of skin yellowness. Methods: Perceived facial skin yellowness was evaluated through three observation and rating tests involving 170 female participants. Standardized lighting and screen settings ensured consistent evaluations of randomized full face and skin‐tone‐adjusted images. The correlation of yellowness observation and clinical parameters was identified, helping to decode the parameters that determine perception. Results: The pair test showed that not only b * but also L * and skin diffused reflection determined yellowness perception commonly across age. Rating test on artificial face images confirmed the importance of both b * and L *. A preliminary model on colorimetric parameters was derived: Perceived Yellowness = 0.42 b * − 0.2 L * + 9.01. Further pair test demonstrated that perceived skin yellowness varied seasonally, suggesting an influence of sun exposure. Conclusion: This study reveals the correlation of skin yellowness perception and clinical parameters, especially the contribution of relevant colorimetric parameters. From a third‐person perspective, b *, L * and diffused reflection are key determinants of perceived skin yellowness. The observed seasonal variation in yellowness perception indicated a perceivable “seasonal skin yellowing.” The findings provided new insights for developing treatments for skin aging yellowness, photoprotection and modulation of colorimetric parameters ( L * and b *) and optical parameter (reflection) are highlighted as important clinical targets.

Hyperpigmentation disorders affect a large proportion of the population, significantly impacting their quality of life and carrying considerable social stigma. This growing global concern results in a strong demand for effective treatments. A rich body of literature proposes numerous active ingredients to solve hyperpigmentation concerns. At the same time, the complex regulation of skin pigmentation is much better understood with increased knowledge on the physiopathology of pigmentary disorders, beyond the sole melanogenesis, including the whole tissue environment of melanocytes. The abundance of mechanistic in vitro and in vivo scientific data makes it challenging for non-expert clinicians to identify the optimal care for patients. The aim of this review is to propose state-of-the-art of topical solutions with actives that have demonstrated conclusive clinical efficacy. It analyzes the different mechanisms involved, including the melanogenesis pathway and others addressing the melanocyte microenvironment. This review first examines the prevention of pigmentary disorders and the importance of a broad-spectrum photoprotection including the whole UV spectrum but also visible light in managing hyperpigmentation. The use of antioxidants to combat oxidative stress and complement photoprotection is also discussed. The following section reviews actives targeting the modulation of melanogenesis. It examines tyrosinase inhibitors, which are still widely used to manage hyperpigmentation problems, as well as new compounds targeting downstream pathways. Other clinically effective interventions include the normalization of epidermal homeostasis and the active restoration of the dermal fibroblastic microenvironment, together with anti-inflammatory agents and those aimed at reducing vascularization impact. Finally, this review highlights the value of combined approaches which have been shown to improve clinical efficacy. This suggests that future research should focus on well-tolerated, multifaceted therapies to effectively treat melanin hyperpigmentary disorders.