Amaç: Bu çalışmada dimenhidrinat’ın erken dönem civciv embriyo modelinde nöral tüp gelişimi üzerindeki etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmada 32 fertil, spesifik patojen olmayan yumurta kullanıldı. Tüm yumurtalar her bir grupta 8 adet olacak şekilde dört gruba ayrıldı. İnkübasyonun 28. saatinde deney gruplarına üç farklı dozda (0,7, 1,4, 2,1 mg/kg) dimenhidrinat ve kontrol grubuna serum fizyolojik enjekte edildi. İnkübasyonun 48. saatinde tüm embriyolar diseke edildi ve ışık mikroskobu altında histolojik olarak değerlendirildi. Bulgular: Kontrol, düşük, orta ve yüksek doz grubu embriyoları morfolojik olarak değerlendirildiğinde, kraniokaudal uzunluk ortalamaları sırasıyla; 8493,73±1342,90 µm, 5743,61±770,3 µm, 5572,62±315,32 µm, 5306,55±1135,99 µm, somit sayıları ortalamaları sırasıyla; 15,91±1,62, 15,38±1,19, 15,13±0,83, 10,63±5,15‘dir. Dimenhidrinat dozundaki artışa bağlı olarak kraniokaudal uzunluklarının ve somit sayılarının azaldığı tespit edildi. Dimenhidrinat doz artışına bağlı olarak nöral tüp açıklığının arttığı belirlendi . Sonuç: Bu çalışmada, erken dönem civciv embriyo modelinde dimenhidrinat uygulanan gruplarda doz artışına bağlı olarak nörogenezisin ve morfolojik gelişimin olumsuz etkilendiği görüldü.

Objective Post-ERCP pancreatitis (PEP) is the most common complication of ERCP. Identifying simple and accessible biomarkers to predict PEP risk may enhance patient safety and guide clinical decisions. Material and Methods This retrospective, single-center study included 613 adult patients who underwent ERCP between January 2017 and December 2024. Demographic data, comorbidities, procedural details, and preoperative laboratory parameters were collected from institutional electronic health records. The primary outcome was the development of PEP, defined by standard diagnostic criteria. Results Post-ERCP pancreatitis occurred in 52 patients (8.5%). Demographic characteristics and comorbidities, including age, sex, body mass index, diabetes mellitus, and hypertension, were not significantly associated with PEP. Pancreatic duct cannulation was significantly more frequent among patients with PEP (53.8% vs. 24.8%, p < 0.001) and remained an independent risk factor in multivariable analysis (aOR: 3.05, 95% CI: 1.65–5.64, p < 0.001). Patients who developed PEP had higher preoperative neutrophil-to-lymphocyte ratio (NLR) (3.7 ± 1.9 vs. 2.9 ± 1.5, p = 0.001) and C-reactive protein (CRP) levels (18.5 ± 11.2 vs. 11.4 ± 8.3 mg/L, p = 0.001). In adjusted analysis, both NLR (aOR: 1.14, 95% CI: 1.02–1.28, p = 0.02) and CRP (aOR: 1.04, 95% CI: 1.01–1.08, p = 0.008) remained statistically significant but modest independent predictors of PEP. ROC analysis demonstrated limited discriminative ability for both NLR (AUC: 0.64) and CRP (AUC: 0.66), with moderate sensitivity and specificity. Conclusion Elevated preoperative NLR and CRP levels, together with pancreatic duct cannulation, were independently associated with an increased risk of post-ERCP pancreatitis. Although these inflammatory markers demonstrated statistically significant associations, their predictive strength was modest. Therefore, NLR and CRP should be interpreted as supportive parameters rather than standalone predictors and may contribute to pre-procedural risk stratification when integrated with established clinical and procedural risk factors. Further prospective, multicenter studies are warranted to validate these findings and clarify their role in clinical practice.

Introduction: This study aimed to evaluate the association between treatment modality, intervention timing, and clinical outcomes in patients aged 65 years or older with acute mesenteric ischemia (AMI). Methods: This multicenter retrospective cohort study included 126 patients aged 65 years or older who were diagnosed with AMI between January 2015 and December 2025. Patients were classified according to treatment modality as endovascular treatment, open surgery, or conservative management. The primary outcome was 30-day mortality. Secondary outcomes included in-hospital mortality, intensive care unit admission, length of hospital stay, complications, and reoperation. Propensity score–based inverse probability of treatment weighting (IPTW) and multivariable logistic regression analyses were performed to reduce potential confounding. Results: The 30-day mortality rate was lower in the endovascular treatment group (26.2%) than in the open surgery (45.5%) and conservative management (45.0%) groups (p=0.041). Delayed intervention (>12 hours) was associated with an increased risk of mortality (OR: 2.68; 95% CI: 1.18–6.09; p=0.018). Serum lactate level, age, and Charlson Comorbidity Index were identified as independent predictors of 30-day mortality. In the IPTW-adjusted analysis, open surgery was associated with higher mortality compared with endovascular treatment (OR: 1.94; 95% CI: 1.05–3.58; p=0.034). Conclusion: Treatment modality and timing of intervention appear to be associated with clinical outcomes in elderly patients with AMI. Endovascular treatment was associated with lower 30-day mortality, whereas delayed intervention was linked to poorer outcomes. However, these findings should be interpreted cautiously because of the retrospective study design and the possibility of residual confounding.

Aims: The aim of this study was to investigate the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and the development of transient hypocalcemia in patients undergoing total thyroidectomy.Methods: In this retrospective cohort study, 84 adult patients who underwent total thyroidectomy between January 2015 and December 2025 were evaluated. Patients were grouped according to the presence of transient hypocalcemia, defined as serum calcium

OBJECTIVE: Infrared thermography is a noninvasive imaging technique that measures skin surface temperature and may reflect underlying inflammatory activity. However, its diagnostic role in thyroiditis remains unclear. This study evaluated the diagnostic performance of infrared thermography in thyroiditis and its relationship with thyroid function tests (TFTs) and inflammatory markers.MATERIAL AND METHODS: This retrospective study included 144 patients (72 with thyroiditis and 72 controls). Thermal images obtained using a portable infrared thermal camera (FLIR One Edge Pro®) were analyzed. Thyroid surface temperature parameters were compared between groups and their relationship with thyroid function tests and inflammatory markers was evaluated.RESULTS: Mean thyroid surface temperature and temperature asymmetry were significantly higher in the thyroiditis group (36.8 ± 0.5 °C vs. 36.1 ± 0.4 °C; 0.54 ± 0.27 °C vs. 0.18 ± 0.09 °C; both p < 0.001). Surface temperature correlated positively with C-reactive protein (CRP) (r = 0.61) and anti–thyroid peroxidase (anti-TPO) (r = 0.57), and negatively with free thyroxine (fT4) (r = −0.52) (all p < 0.001). A temperature cut-off > 36.4 °C predicted thyroiditis with an AUC of 0.88. Multivariate analysis identified mean thyroid surface temperature (OR = 5.21), anti-TPO (OR = 3.76), and CRP (OR = 1.38) as independent predictors.CONCLUSIONS: Infrared thermography may serve as a useful noninvasive adjunct in the evaluation of thyroiditis. Elevated thyroid surface temperature and asymmetry correlate with inflammatory and biochemical markers of thyroid dysfunction. These findings suggest that thermographic assessment may contribute to clinical decision-making as a complementary tool. Prospective multicenter studies are needed to confirm these findings.