With the advancement of building industrialization and the concept of sustainable development, modular and disassemblable buildings, as an efficient and environmentally friendly architectural form, have significant potential in scenarios such as emergency housing and rural construction. In response to issues such as insufficient component compatibility, low disassembly and assembly efficiency, and low integration, this paper proposes a solution based on the Design for Manufacturing and Assembly (DFMA) theory. Taking M-Box 1.0 as a case study, it explores design strategies from four aspects: product modularization, logistics optimization, rational disassembly and assembly, and component integration. Data shows that compared with the construction and assembly of the same-scale steel structure, the construction time of this building is shortened by 86%, the construction period is compressed by 36%, and the cost is reduced by 73.3%. The research reveals the advantages of DFMA-oriented design and has substantial significance for promoting the efficient and energy-saving development of building industrialization.