Nowadays, a high number of diseases are connected to bacterial or viral infections. The treatment of the patients is getting more and more difficult, the reason being the smart strategies that microbes facilitate to escape the antibiotics' influence. Purpose: This review presents a literature investigation conducted in 2025 regarding platinum as a source for developing metalloantibiotics and antibacterial agents. Material/Methods: A study on scientific publications was done in different databases, using the necessary search terms in the scientific literature. Results and discussion: We focus on the various mechanisms that could be used with the participation of platinum complexes and nanoparticles in order to affect the development of bacterial biofilms and the spread of infections. We discuss the beneficial combinations of platinum compounds with other drugs or metals that reveal a synergistic effect in the fight against microbial growth. The conclusion is that the use of platinum complexes and antimicrobial drugs is getting a deeper perspective for developing new combination treatments as well as new metallodrugs that are potent and could have more effective application against antimicrobial resistance and for the treatment of various infections.

The disease COVID-19, which has befallen mankind in recent years, was a challenge that we had not faced for centuries. The first registered patient case was in China. This review is performed by the inspection of a large body of worldwide investigations conducted in the peak period of the disease’s progress. The disease is spread by airborne droplets and develops mainly with fever, cough, sputum, and shortness of breath. Laboratory tests show leukopenia, lymphopenia, a decrease in the levels of sodium, potassium, and calcium, and an increase in the levels of CRP, LDH, and D-dimer. Radiological changes in most cases are bilateral and of the “ground glass” type in the lower parts of the lungs. The most severe complication of COVID-19 pneumonia is ARDS. The risk groups are people with chronic lung diseases, the elderly, and those who are overweight. This article analyzes and summarizes the main characteristics of SARS-CoV-2 pneumonia in order to better understand and apply better clinical management of this condition.

Background: Syphilis is a chronic systemic disease caused by Treponema pallidum. It is called the "great imitator" due to its diverse clinical manifestations. In the classical development of acquired syphilis, three clinical stages are recognized – primary, secondary, and tertiary. The aim of our study is to outline current aspects of the clinical management of the multifaceted disease, through the presentation of a clinical case - secondary syphilis in a man. Material/Methods: The medical documentation was used in strict compliance with the principles of research ethics for access to documentation and confidentiality of information. An analysis of regulatory documents and scientific publications on the discussed problem was applied. Results: We present a clinical case of a 53-year-old man admitted for surgical treatment in the otolaryngology department - for four months with pain when swallowing, rashes on the palms, "sore" on the penis. Of the tests performed, only the serological results for syphilis were positive. Consultations were conducted with an infectious disease specialist and a dermatovenereologist - given the anamnestic, clinical and serological results, the surgical intervention was canceled and a diagnosis of secondary syphilis was made. Antibiotic therapy and serological diagnostics were performed. The patient remains under observation. Conclusions: The true incidence of secondary syphilis is difficult to determine due to the variety of clinical symptoms and diagnostic difficulties. Clinical management - diagnostics, timely treatment and follow-up of this disease with many faces is a problem of interdisciplinary medical nature and great social importance.

Cutaneous larva migrans (CLM) is a zoonotic parasitic infection traditionally associated with tropical and subtropical regions. In recent years, autochthonous cases have been reported in various European countries, suggesting a possible change in the epidemiological profile of the disease. We present a case of a patient with no history of international travel who developed a typical serpiginous, migrating skin lesion after local exposure. The diagnosis was made clinically, and treatment with albendazole resulted in rapid clinical improvement. To our knowledge, this is the first published probable autochthonous case of CLM in Bulgaria. The case highlights the role of climate change in expanding the geographical scope of the parasitosis and the need for increased clinical vigilance at the primary care level.

This article presents a study on the level of anxiety regarding the spread of COVID-19 among social work professionals, their attitude towards vaccines, and the influence of certain demographic characteristics. Purpose: The main purpose of the study is to assess the levels of anxiety, attitudes toward vaccines, and trust in information sources among social work professionals in order to support the development of more effective strategies for enhancing support and protecting their mental health. Materials/Methods: An online survey was conducted with 316 social work professionals from several Bulgarian regions, and statistical analyses (SPSS) were applied to examine anxiety, vaccine attitudes, and demographic influences. Results: The analysis shows that most professionals experience high anxiety (61%) regarding COVID-19, exhibit mixed attitudes toward vaccines (41% positive, 46% hesitant), and demonstrate varying levels of trust in medical information, with demographic factors significantly affecting these variables. Conclusions: The obtained results provide grounds for recommendations that contribute to improving the public health of those working in helping professions.