Digital transformation is gradually emerging as a core driver of high-quality economic development and the achievement of sustainable development goals. As the core engine of the digitalization process, digital innovation is becoming a key supporting force for activating the value of digital elements and fostering a new development pattern. Based on panel data from 31 provincial-level administrative regions in China spanning from 2019 to 2023, we undertook an in-depth exploration of how information ecosystems and digital transformation drivers synergistically enhance regional digital innovation capabilities and their substitutive relationships. The results show the following: Firstly, technological, subject, information, and environmental conditions cannot individually constitute the necessary conditions for a high level of regional digital innovation capacity. Secondly, three types of conditional configurations, namely technology–environment-driven, subject–environment-driven, and balance-driven, are its main driving paths, with significant substitution effects among these conditions. This study provides theoretical and empirical evidence for formulating region-specific strategies to optimize digital innovation capacity and helps formulate differentiated digital development strategies based on regional resource endowments and institutional characteristics, ultimately promoting the construction of a more balanced and resilient digital innovation ecosystem.