Dr. Ayoade is an infectious diseases expert whose research focuses on the neuroimmune, biobehavioral, and inflammatory pathways that influence infectious diseases and their effects on the nervous system. His work also examines the roles of the resident microbiome, accelerated aging, inflammation, and immune activation in infections caused by oncogenic viruses and in cancer among people with and without HIV. A major focus of his research is understanding how inflammation and immune activation drive pathogenic changes and contribute to adverse clinical outcomes. By defining the underlying mechanisms and neural pathways involved in these conditions, his work seeks to identify targets for interventions that can prevent disease, enable earlier diagnosis, and mitigate complications. Dr. Ayoade also studies strategies to improve the diagnosis and management of community-acquired and healthcare-associated meningitis and ventriculitis. He has participated in several clinical diagnostic and therapeutic trials, has been an invited speaker on a variety of platforms, and has received numerous awards from regional and national professional societies.