Background/Objectives: Health literacy has an impact on students’ reproductive health. Therefore, the objective of our study is to systematically examine, identify, and summarize all research on the role of health literacy in fertility awareness and reproductive health among university students in order to understand how health literacy influences reproductive health outcomes in this population. Methods: Using the PRISMA guidelines, a comprehensive systematic search was conducted using electronic databases, such as PubMed, EMBASE, CINAHL, Scopus, and Google Scholar. The protocol was registered in the Prospective Register for Systematic Reviews (PROSPERO, CRD 42024566268). All studies were imported into EndNote software and screened using a two-level title/abstract screening process. The included studies were narratively summarized. Results: The database search identified 1360 articles; 116 duplicates were removed, and thus, 1244 were initially screened, leading to 1133 exclusions. A total of 111 articles underwent full screening, and 94 were then excluded. A total of 14 articles were included for data extraction. Health literacy impacts university students’ behaviour, fertility awareness, and reproductive health knowledge. Students with higher health literacy show more understanding of critical topics such as fertility and emergency contraception. Socioeconomic factors play a crucial role in shaping health literacy and reproductive choices, while gender disparities highlight the need for targeted educational interventions, particularly for male students. Effective educational programs have been shown to enhance health literacy. Additionally, technology integration serves as a valuable tool for disseminating reproductive health information. Cultural context also plays a vital role in influencing health literacy. Conclusions: The findings of this study emphasize the importance of comprehensive strategies to enhance health literacy among university students, and future research should focus on developing and evaluating targeted educational programs that address gender disparities and socioeconomic factors influencing health literacy.

Background/Objectives: Infertility imposes substantial psychosocial burdens on affected individuals, often resulting in a decline in quality of life comparable to that experienced in chronic diseases. Exploring lifestyle and health awareness-related factors is essential to develop complex, multidisciplinary approaches. This study investigated the associations between the components of 24-h movement behaviour (physical activity, sedentary lifestyle, sleep), health literacy, fertility awareness, and general and infertility-specific quality of life. Additionally, the study assessed whether these factors could predict quality of life outcomes in women living with infertility. Methods: A cross-sectional study was conducted using questionnaire-based data collection in four fertility centres in Hungary. The convenience sample included 361 women aged 18–45 years with a documented infertility diagnosis. Validated questionnaires were used to assess health literacy (BRIEF), fertility awareness (FAS), physical activity (GPAQ-H), sleep quality (AIS), and quality of life (WHOQOL-BREF and FertiQoL). Data analysis included Kolmogorov–Smirnov tests, Spearman correlations, and generalised linear modelling (GLM), with statistical significance set at p < 0.05. Results: Based on the FAS, 77.8% of participants (n = 274) self-reported being adequately informed; however, objective knowledge scores accounted for only 48.5% of the possible total, indicating limited knowledge. Fertility awareness positively correlated with recreational physical activity (ρ = 0.156; p = 0.003). Recreational physical activity showed low but significant positive associations with all quality-of-life dimensions (e.g., psychological well-being: r = 0.177; p ≤ 0.002), whereas sedentary time was negatively associated with psychological well-being (r = −0.109) and social relationships (r = −0.118). Sleep duration correlated positively while sleep quality problems correlated negatively with FertiQoL scores (r = −0.339; p ≤ 0.001). Better sleep quality, lower sedentary time, and higher health literacy were positive predictors of infertility-specific quality of life, whereas higher fertility awareness showed a paradoxical adverse effect. Conclusions: These findings highlight the role of 24-h movement behaviour and health awareness in improving quality of life among women with infertility. The study supports the need for tailored, multi-component lifestyle interventions to promote physical, mental, and psycho-social well-being.