Introduction: Fractures with delayed healing can be a serious complication, especially for athletes depending on quick return to sports. To our knowledge, no cases of increased healing of delayed union fractures with autologous biomedical interventions have been reported. Case presentation: A 33-year-old Swedish professional boxer with a fractured humerus with a delayed union and a partially torn supraspinatus tendon was treated with injections of liquid platelet-rich fibrin and heat-coagulated albumin gel. He recovered almost completely from both injuries in only 1 month and could return to professional boxing in 3 months. Conclusion: This case raises the hypothesis that liquid platelet-rich fibrin and heat-coagulated albumin gel may be an effective, minimally invasive intervention in fractures with a delayed union. Further research is required to test this theory.

Introduction: Exosomes, nanosized vesicles derived from various cellular sources, hold immense potential in modulating physiological processes and promoting tissue repair. Exosomes derived from amniotic fluid show significant promise in regenerative medicine and tissue repair. To our knowledge, there are no reported cases of reduction of chronic pain due to bone- and cartilage degeneration reported after exosome treatment. Case presentation: Three male patients, all with chronic pain and reduced physical function due to bone- or cartilage degeneration all showed a remarkable reduction in pain and increase in function after one single injection of amniotic-derived exosomes. Conclusion: These cases raise the hypothesis that amniotic-derived exosomes may be an effective intervention in the treatment of degenerative bone- and cartilage diseases. Especially in combination with other regenerative medicine interventions. Further research is required to test this theory.

Background: Knee pain is one of the most frequent musculoskeletal symptoms in young physically active males. In some cases, it is very painful, can be hard to treat, and often leads to heterotopic ossification of the patellar tendon. To the best of our knowledge, there are no reported cases of remission of ossification after clinical intervention. Case Presentation: A 13-year-old Swedish boy with a 3-year anamnesis of severe Osgood-Schlatter with significant ossification of the patellar tendon at the point of tuberositas tibiae, was treated with injections of liquid platelet-rich fibrin concentrated platelet rich fibrin and heat coagulated albumin platelet rich fibrin gel (ALB-PRF) using a horizontal centrifuge system. He recovered and presented a near complete remission of ossification of the patellar tendon 2 months after treatment and could return to sport after a 3-year break. Conclusion: This case raises the hypothesis that liquid ALB-PRF gel may be an effective intervention in the treatment of Osgood-Schlatter disease. Further research is required to test this theory.

Regenerative medicine and osteoarthritis: SVF, exosomes and beyond: Torbjörn Ogéus from Stockholms Led- & Smärtspecialist guides us through the evolving science of stromal vascular fraction, exosomes, and beyond in regenerative medicine and osteoarthritis. Osteoarthritis (OA), a chronic degenerative joint condition, affects hundreds of millions worldwide and remains a leading cause of disability and reduced quality of life. While traditional treatments focus on symptom control – primarily pain management and surgical intervention – the field of regenerative medicine is rapidly rewriting the narrative.