Background: Chimeric antigen receptor (CAR) T-cell therapy has transformed the therapeutic landscape for relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Our study aims to describe the clinical outcomes of CAR T-cell therapy in patients with R/R DLBCL treated at a single regional center in Italy, with the goal of comparing these outcomes to those reported by high-volume academic centers. Methods: Data were retrospectively collected from a cohort of consecutive 41 patients who underwent to CD19 CAR-T infusion from June 2020 until September 2024 at CAR-T center of Reggio Calabria (Italy). Results: The median age was 66 years, 60.9% were refractory to their most recent regimen, and 24.4% had previously failed autologous stem cell transplant. Bridging therapy was administered in 82.9% of cases. A total of 27 patients (65.8%) received Axi-cel, and 14 (34.2%) received Tisa-cel. At median follow-up of 6.9 months, the best ORR and CR rate were 63.4% and 51.2%, respectively. Median PFS was 3 months, and median OS was 8.4 months. A total of 81.4% of patients developed a CRS, grade 1 in most cases (78.4%); 26.8% developed ICANS: two (5.4%) and three (8.1%) had grade 2 and 3, respectively. In univariate analyses, early response predicted longer survival, whereas high tumor burden and more than one extranodal site were associated with worse outcomes. Conclusions: Our retrospective cohort study reports similar data in terms of clinical response as compared to pivotal trials and other reports, confirming that CAR-T may offer more durable response rates and longer progression-free intervals in R/R DLBCL in our real-world context.

Breast cancer (BC) surgery often reduces upper limb range of motion (ROM), negatively affecting quality of life. Since most research focuses on early recovery, this study investigates differences in ROM between the surgical (SA) and non-surgical (NS) arms in BC survivors and between recent (2.5 years—NR) surgery groups. Upper limb kinematics (flexion–extension, abduction, internal–external rotation) were recorded using inertial measurement units in 26 BC survivors (age: 48.92 ± 7.89 years; stature: 1.57 ± 0.05 m; mass: 66.59 ± 14.07 kg; BMI: 27.14 ± 5.71 kg/m²). ROM, angular velocity, and movement smoothness were analyzed. The SA group demonstrated reduced ROM during flexion (p = 0.023) and extension (p = 0.005) compared to the NS group. Within the RS group, the SA group exhibited lower ROM (p = 0.005), reduced peak angular velocity (p = 0.008), and average angular velocity (p = 0.006) during extension compared with the NR group. Additionally, the average extension angular velocity of the arm among the NS group was higher in the RS group than in the NR group. BC surgery causes persistent upper limb kinematic impairments, mainly during flexion and extension, which can be observed up to six years after surgery. Therefore, early and continuous tailored physical exercise is highly recommended to mitigate these long-term functional deficits.